| Identification | Back Directory | [Name]
6-AMino-4-chloro-nicotinic acid | [CAS]
1060808-94-7 | [Synonyms]
6-AMino-4-chloro-nicotinic acid
6-Amino-4-chloropyridin-3-carboxylic acid
6-amino-4-chloropyridine-3-carboxylic acid
6-AMino-4-chloro-3-pyridinecarboxylic acid
3-Pyridinecarboxylic acid, 6-amino-4-chloro- | [Molecular Formula]
C6H5ClN2O2 | [MDL Number]
MFCD13189221 | [MOL File]
1060808-94-7.mol | [Molecular Weight]
172.57 |
| Chemical Properties | Back Directory | [Boiling point ]
383.1±42.0 °C(Predicted) | [density ]
1.577±0.06 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Inert atmosphere,2-8°C | [pka]
1.65±0.25(Predicted) | [Appearance]
White to light yellow Solid |
| Hazard Information | Back Directory | [Synthesis]
General procedure for the synthesis of 4-chloro-6-aminonicotinic acid from 6-amino-4-chloronicotinonitrile: Concentrated sulfuric acid (98%, 0.5 mL) was slowly added dropwise to a stirring suspension of 6-amino-4-chloronicotinonitrile (0.020 g, 0.130 mmol) in water (1 mL). The reaction mixture was heated to 100 °C and maintained for 18 hours. Upon completion of the reaction, it was cooled to room temperature and slowly added dropwise to a saturated sodium bicarbonate solution (2 mL) containing ice and the pH was adjusted to about 2. The resulting precipitate was collected by filtration, washed with water (2 mL), and subsequently air-dried to yield 4-chloro-6-aminonicotinic acid (0.019 g, 0.110 mmol, 84% yield) as a colorless powder, [M + H]+ m/z = 173.0. | [References]
[1] Patent: WO2013/91011, 2013, A1. Location in patent: Page/Page column 64; 65
[2] European Journal of Medicinal Chemistry, 2014, vol. 86, p. 31 - 38 |
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Adamas Reagent, Ltd.
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Heterochem
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