| Identification | Back Directory | [Name]
4,6-dichloronicotinaldehyde | [CAS]
1060811-62-2 | [Synonyms]
4,6-dichloronicotinaldehyde
4,6-Dichloropyridine-3-carbaldehyde
4,6-Dichloronicotinaldehyde(WXC01807)
4,6-Dichloropyridine-3-carboxaldehyde
3-Pyridinecarboxaldehyde, 4,6-dichloro-
4,6-dichloronicotinaldehyde ISO 9001：2015 REACH | [Molecular Formula]
C6H3Cl2NO | [MDL Number]
MFCD12025485 | [MOL File]
1060811-62-2.mol | [Molecular Weight]
176 |
| Chemical Properties | Back Directory | [Boiling point ]
268.2±35.0 °C(Predicted) | [density ]
1.488±0.06 g/cm3(Predicted) | [storage temp. ]
Inert atmosphere,Store in freezer, under -20°C | [pka]
-1.17±0.10(Predicted) | [Appearance]
White to light green Solid | [InChI]
InChI=1S/C6H3Cl2NO/c7-5-1-6(8)9-2-4(5)3-10/h1-3H | [InChIKey]
AKYJFAHYRMPRDS-UHFFFAOYSA-N | [SMILES]
C1=NC(Cl)=CC(Cl)=C1C=O |
| Hazard Information | Back Directory | [Synthesis]
Part II- Synthesis of 4,6-dichloropyridine-3-carbaldehyde: (4,6-dichloropyridin-3-yl)methanol (4.9 g, 28 mmol) was dissolved in trichloromethane (100 mL). Subsequently, manganese dioxide (24 g, 280 mmol) was added and the reaction mixture was stirred at 75 °C for 12 hours. Upon completion of the reaction, the mixture was cooled to room temperature, filtered through a pad of diatomaceous earth and the filtrate was concentrated under reduced pressure to give 4,6-dichloropyridine-3-carbaldehyde. The mass of the product was 2.9 g in 90% yield. Liquid chromatography-mass spectrometry (electrospray ionization) analysis: calculated value C6H3Cl2NO = 175; measured value [M + H]+ signal is weak. | [References]
[1] Patent: WO2013/169704, 2013, A2. Location in patent: Paragraph 0231
[2] Patent: CN106810558, 2017, A. Location in patent: Paragraph 0158; 0162; 0163
[3] Patent: CN106810559, 2017, A. Location in patent: Paragraph 0162; 0167; 0170; 0171
[4] Patent: WO2016/128529, 2016, A1. Location in patent: Paragraph 01364; 01367; 01368
[5] Patent: WO2018/15410, 2018, A1. Location in patent: Paragraph 0284; 0288-0290 |
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