| Identification | Back Directory | [Name]
4-(1,3-dithiolan-2-yl)-N-(3-hydroxypyridin-2-yl)benzamide | [CAS]
1060968-92-4 | [Synonyms]
E17241
4-(1,3-dithiolan-2-yl)-N-(3-hydroxypyridin-2-yl)benzamide
Benzamide, 4-(1,3-dithiolan-2-yl)-N-(3-hydroxy-2-pyridinyl)- | [EINECS(EC#)]
829-239-6 | [Molecular Formula]
C15H14N2O2S2 | [MDL Number]
MFCD11774214 | [MOL File]
1060968-92-4.mol | [Molecular Weight]
318.414 |
| Chemical Properties | Back Directory | [Boiling point ]
515.7±50.0 °C(Predicted) | [density ]
1.431±0.06 g/cm3(Predicted) | [solubility ]
DMSO: Soluble: =10 mg/ml | [pka]
7.60±0.10(Predicted) |
| Hazard Information | Back Directory | [Uses]
E17241 is an inducer of the expression of ABCA1 that increases the protein levels of ABCA1 in RAW 264.7 macrophages. E17241 is also an agonist of peroxisome proliferator-activated receptors (PPARs ). E17241 decreases plasma glucose levels and body weight in KKAy diabetic mice fed a high-fat and high-glucose (HFHG) diet[1][2]. | [References]
[1] Sheng R, et al. A pan-PPAR agonist E17241 ameliorates hyperglycemia and diabetic dyslipidemia in KKAy mice via up-regulating ABCA1 in islet, liver, and white adipose tissue. Biomed Pharmacother. 2024 Mar;172:116220. DOI:10.1016/j.biopha.2024.116220
[2] Xu Y, et al. E17241 as a novel ABCA1 (ATP-binding cassette transporter A1) upregulator ameliorates atherosclerosis in mice[J]. Arteriosclerosis, Thrombosis, and Vascular Biology, 2021, 41(6): e284-e298. DOI:10.1161/ATVBAHA.120.314156 |
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