| Identification | Back Directory | [Name]
valproic acid hydroxamate | [CAS]
106132-78-9 | [Synonyms]
VAHA
VAHA >=98% (HPLC)
valproic acid hydroxamate
Valproyl hydroxamic acid, VPA-HA | [Molecular Formula]
C8H17NO2 | [MDL Number]
MFCD12756348 | [MOL File]
106132-78-9.mol | [Molecular Weight]
159.23 |
| Chemical Properties | Back Directory | [Melting point ]
123 °C | [density ]
0.968±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
DMSO: ≥25mg/mL | [form ]
powder | [pka]
9.73±0.40(Predicted) |
| Hazard Information | Back Directory | [Uses]
VAHA may be used in cell signaling studies. | [Definition]
ChEBI: N-hydroxy-2-propylpentanamide is a hydroxamic acid. | [Biological Activity]
Hydroxamic acid derivatives of valproic acid exhibit anticonvulsant activity with no teratogenic activity in mouse neural tube defect model. It is effective in the treatment of bipolar disorders. ''VAHA (Valproyl hydroxamic acid) is an HDAC inhibitor with less activity than valproic acid against Class I enzymes but much greater Class II activity |
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Energy Chemical
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Merck KGaA
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CHEMICAL LAND21
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