| Identification | Back Directory | [Name]
Compound 23 | [CAS]
1062169-46-3 | [Synonyms]
WYE-23
Compound 23
mTOR Inhibitor, WYE-23
methyl 4-(6-(4-[(cyclopropylcarbamoyl)amino]phenyl)-4-morpholin-4-yl-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate | [Molecular Formula]
C26H32N8O4 | [MOL File]
1062169-46-3.mol | [Molecular Weight]
520.58 |
| Chemical Properties | Back Directory | [density ]
1.52±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: soluble | [form ]
White powder solid. | [pka]
13.53±0.20(Predicted) |
| Hazard Information | Back Directory | [Uses]
mTOR inhibitor WYE-23 is a mTOR inhibitor, and IC50 is 0.45 nM. It is selective to PI3Kα and IC50 is 661 nM. mTOR inhibitor WYE-23 has antitumor activity[1][2]. | [storage]
Store at -20°C | [References]
[1] Nikola P. Pavletich et al. mTOR CRYSTALS AND MODULATORS. WO2014176281A1.2014-10-30.
[2] Zask A, et al. ATP-competitive inhibitors of the mammalian target of rapamycin: design and synthesis of highly potent and selective pyrazolopyrimidines. J Med Chem. 2009 Aug 27;52(16):5013-6. DOI:10.1021/jm900851f |
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