| Identification | Back Directory | [Name]
THIOPERAMIDE MALEATE | [CAS]
106243-16-7 | [Synonyms]
Thiop
MR 12842
thioperamide
THIOPERAMIDE MALEATE
THIOPERAMIDE MALEATE SALT
THIOPERAMIDE MALEATE (MR 12842) POTENT A ND SELECTIVE
N-Cyclohexyl-4-(imidazol-4-yl)-1-piperidinecarbothioamide
N-Cyclohexyl-4-(1H-imidazol-4-yl)-1-piperidinecarbothioamide
N-CYCLOHEXYL-4-(1H-IMIDAZOL-5-YL)-1-PIPERIDINECARBOTHIOAMIDE
N-Cyclohexyl-4-(1H-imidazol-5-yl)piperidine-1-carbothioamide
1-Piperidinecarbothioamide, N-cyclohexyl-4-(1H-imidazol-5-yl)-
N-CYCLOHEXYL-4-(IMIDAZOL-4-YL)-1-PIPERIDINECARBOTHIOAMIDE MALEATE
N-CYCLOHEXYL-4-(1H-IMIDAZOL-4-YL)-1-PIPERIDINECARBOTHIOAMIDE MALEATE | [Molecular Formula]
C15H24N4S | [MDL Number]
MFCD00083209 | [MOL File]
106243-16-7.mol | [Molecular Weight]
292.44 |
| Hazard Information | Back Directory | [Uses]
Thioperamide is a highly potent and selective ligand for histamine H3-receptors. | [Definition]
ChEBI: Thioperamide is a primary aliphatic amine. | [Biological Activity]
Potent histamine H 3 and H 4 antagonist/inverse agonist. K i values are 25 and 27 nM for human recombinant H 3 and H 4 receptors respectively. Blocks eosinophil shape change (IC 50 = 1.4 μ M) and chemotaxis (IC 50 = 519 nM) induced by histamine. Freely crosses the blood-brain barrier. Also available as part of the Histamine H 3 Receptor Tocriset™ . | [in vivo]
Thioperamide (5-20 mg/kg; i.p.) is able to facilitate reconsolidation of a contextually-conditioned fear memory in C57BL/6J mice[3]. | Animal Model: | Naive female C57BL/6J mice[3] | | Dosage: | 5, 10 or 20 mg/kg | | Administration: | Injections (i.p.) | | Result: | Facilitated reconsolidation of a contextually-conditioned fear memory. |
| [IC 50]
H3 Receptor | [storage]
Store at -20°C |
|
|