| Hazard Information | Back Directory | [Description]
WK-298 is a potent inhibitor of the MDM2/MDMX-p53 interaction. | [Uses]
WK298 is a potent inhibitor of the MDM2/MDMX-p53 interaction with good anti-tumor activity. WK298 can fully activate the p53 pathway by inhibiting the binding of MDM2 and MDMX to p53. The development of WK298 benefited from a deep understanding of the key elements of the p53-MDM2/MDMX interaction structure[1]. | [References]
[1] Medicinal Chemistry Strategies to Disrupt the p53-MDM2/MDMX Interaction |
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