| Identification | Back Directory | [Name]
DOXACURIUM CHLORIDE | [CAS]
106819-53-8 | [Synonyms]
Nuromax
BW-A938U
Doxacurium
DOXACURIUM CHLORIDE
bis[3-[6,7,8-trimethoxy-2-methyl-1-[(3,4,5-trimethoxyphenyl)methyl]-3,4-dihydro-1h-isoquinolin-2-ium-2-yl]propyl] butanedioate dichloride | [Molecular Formula]
C56H78Cl2N2O16 | [MDL Number]
MFCD00906167 | [MOL File]
106819-53-8.mol | [Molecular Weight]
1106.13 |
| Hazard Information | Back Directory | [Description]
Doxacurium chloride is an injectable, noncumulative, nondepolarizing neuromuscular
blocking agent which exhibits no significant cardiovascular effects. It is a mixture of
(lR, l′S, 2S, 2′R), (lR, l′R, 2S, 2′s) and (lS, l′S, 2R, 2′R) isomers of a
bis-benzylisoquinolinium diester.Doxacurium chloride provides satisfactory
intubation with duration of action similar to d-tubocurarine or pancuronium. However,
it is reported to be 2 to 3 times as potent as pancuronium. | [Originator]
Wellcome (United Kingdom) | [Uses]
Neuromuscular blocking agent. | [Brand name]
Nuromax (Abbott). | [General Description]
The molecular structure of doxacuriumchloride, 1,2,3,4-tetrahydro-2-(3-hydroxypropyl)-6,7,8-trimethoxy2-methyl-1-(3,4,5-trimethoxybenzyl) isoquinoliniumchloride succinate (Nuromax), provides thepossibility for 10 stereoisomers: 4 d,l pairs and two mesoforms. Of the 10 stereoisomers, 3 are all-trans configuration,and these are the only active ones. Doxacurium chlorideis a long-acting nondepolarizing blocking agent. The drugdiffers from drugs such as gallium and pancuronium in thatit has no vagolytic activity. It is used as a skeletal musclerelaxant in surgical procedures expected to last longer than90 minutes. | [Pharmacokinetics]
Doxacurium is a mixture of three trans, trans-stereoisomers, a dl pair [(1R,1′R,2S,2′S) and (1S,1′S,2R,2′R)] and a meso form (1R,1′S,2S,2′R).
Doxacurium is hydrophilic, has a small volume of distribution, and is distributed primarily to extracellular fluids. It is not metabolized by plasma
cholinesterase or hepatic enzymes and does not undergo Hofmann elimination. |
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| Company Name: |
LGM Pharma
|
| Tel: |
1-(800)-881-8210 |
| Website: |
www.lgmpharma.com |
| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
|