| Identification | Back Directory | [Name]
Fluo-2 AM | [CAS]
1070771-36-6 | [Synonyms]
Glycine, N-[2-[(acetyloxy)methoxy]-2-oxoethyl]-N-[4-[6-[(acetyloxy)methoxy]-3-oxo-3H-xanthen-9-yl]-2-[2-[2-[bis[2-[(acetyloxy)methoxy]-2-oxoethyl]amino]-5-methylphenoxy]ethoxy]phenyl]-, (acetyloxy)methyl ester | [Molecular Formula]
C51H52N2O23 | [MOL File]
1070771-36-6.mol | [Molecular Weight]
1060.96 |
| Hazard Information | Back Directory | [Biological Activity]
Fluo-2 AM is a cell-permeable fluorescent calcium indicator.1,2 It has been used to measure the activity of the neuropeptide Y4 receptor, as well as to detect intracellular calcium in tetrandine-stimulated primary rabbit corpus cavernosum smooth muscle cells. It binds to calcium (Kd = 290 nM) and displays excitation/emission maxima of 490/515 nm, respectively. Fluo-2 AM is also available in a cell-impermeable form . | [References]
1.Sliwoski, G., Schubert, M., Stichel, J., et al.Discovery of small-molecule modulators of the human Y4 receptorPLoS One11(6)e0157146(2016)
2.Liu, J.-H., Chen, J., Wang, T., et al.Effects of tetrandrine on cytosolic free calcium concentration in corpus cavernosum smooth muscle cells of rabbitsAsian J. Androl.8(4)405-409(2006)
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