| Chemical Properties | Back Directory | [Boiling point ]
330.3±42.0 °C(Predicted) | [density ]
1.225±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMF:10.0(Max Conc. mg/mL);32.23(Max Conc. mM)
DMSO:30.0(Max Conc. mg/mL);96.69(Max Conc. mM)
Ethanol:10.0(Max Conc. mg/mL);32.23(Max Conc. mM)
Ethanol:PBS (pH 7.2) (1:2):0.3(Max Conc. mg/mL);0.97(Max Conc. mM) | [form ]
Liquid | [color ]
Colorless to light yellow |
| Hazard Information | Back Directory | [Description]
GK187 is an inhibitor of Group VIA (GVIA) calcium-independent phospholipase A2 (iPLA2), an enzyme involved in basal cell metabolism. It inhibits GVIA iPLA2 by 99.8% at 0.091 mole fraction in a mixed micelle activity assay and is selective for GVIA iPLA2 over GIVA cPLA2 and GV sPLA2 where it shows less than 25% and 32.8% inhibition, respectively. | [Uses]
GK187 is a very potent and selective GVIA iPLA2 inhibitor. | [References]
[1] VICTORIA MAGRIOTI . New potent and selective polyfluoroalkyl ketone inhibitors of GVIA calcium-independent phospholipase A2[J]. Bioorganic & Medicinal Chemistry, 2013, 21 18: Pages 5823-5829. DOI: 10.1016/j.bmc.2013.07.010 |
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| Company Name: |
BOC Sciences
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| Tel: |
16314854226 |
| Website: |
www.bocsci.com |
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