Back to ChemicalBook Home--->CAS DataBase List--->1073154-85-4

1073154-85-4

1073154-85-4 Structure

1073154-85-4 Structure
IdentificationBack Directory
[Name]

Defactinib
[CAS]

1073154-85-4
[Synonyms]

VS6063
VS-6063
VS 6063
CS-1796
Defactinib
Defactinib (VS-6063
VS-6063; PF-04554878
PF-04554878 Defactinib
Defactinib(PF-04554878)
N-METHYL-4-(4-((3-(N-METHYLMETHYL SULFON
VS-6063; VS6063; VS 6063; PF04554878; PF-04554878; PF 04554878
N-methyl-4-(4-((3-(N-methylmethylsulfonamido)pyrazin-2-yl)methylamino)-5-(trifluoromethyl)pyrimidin-2-ylamino)benzamide
N-methyl-4-[[4-[[3-[methyl(methylsulfonyl)amino]pyrazin-2-yl]methylamino]-5-(trifluoromethyl)pyrimidin-2-yl]amino]benzamide
N-methyl-4-(4-((3-(N-methylmethan-3-ylsulfonamido)pyrazin-2-yl)methylamino)-5-(trifluoromethyl)pyrimidin-2-ylamino)benzamide
N-Methyl-4-[[4-[[[3-[methyl(methylsulfonyl)amino]-2-pyrazinyl]methyl]amino]-5-(trifluoromethyl)-2-pyrimidinyl]amino]benzamide
Benzamide, N-methyl-4-[[4-[[[3-[methyl(methylsulfonyl)amino]-2-pyrazinyl]methyl]amino]-5-(trifluoromethyl)-2-pyrimidinyl]amino]-
N-methyl-4-((4-(((3-(N-methylmethylsulfonamido)pyrazin-2-yl)methyl)amino)-5-(trifluoromethyl)pyrimidin-2-yl)amino)benzamide Defactinib(PF-04554878)(VS-6063)
[Molecular Formula]

C20H21F3N8O3S
[MOL File]

1073154-85-4.mol
[Molecular Weight]

510.49
Chemical PropertiesBack Directory
[density ]

1.495±0.06 g/cm3(Predicted)
[pka]

15.16±0.46(Predicted)
Hazard InformationBack Directory
[Description]

Focal adhesion kinase (FAK) is a non-receptor tyrosine kinase that plays a vital role in many oncogenic pathways. Defactinib is a dose-dependent inhibitor of FAK, with maximal inhibition of FAK autophosphorylation in cells achieved at 10 μM. It is less effective against the related kinase PYK2. Defactinib restores the chemosensitivity of taxane-resistant cells to paclitaxel (Item No. 10461), although it is not cytotoxic alone. Defactinib decreases YB-1 phosphorylation and nuclear accumulation in an Akt-dependent manner. It is orally bioavailable, inhibiting FAK and augmenting paclitaxel action in suppressing the growth and number of ovarian cancer cell tumors in mice.
[Uses]

Defactinib is a selective and orally active FAK inhibitor phase 2. Used in treating cancer patients as it decreases proliferation and increases apoptosis.
1073154-85-4 suppliers list
Company Name: ATK CHEMICAL COMPANY LIMITED
Tel: +86 21 5161 9050/ 5187 7795
Fax: +86 21 5161 9052/ 5187 7796
Website: www.atkchemical.com
Company Name: Hubei Jusheng Technology Co.,Ltd.
Tel: 86-18871470254
Fax: 027-59599243
Website: www.hubeijusheng.com
Company Name: BOC Sciences
Tel: 1-631-485-4226
Fax: 1-631-614-7828
Website: https://www.chemicalbook.com/ShowSupplierProductsList518419/0.htm
Company Name: career henan chemical co
Tel: 0371-55982848 , 15093356674
Fax: 0086-371-86658258
Website: www.coreychem.com
Company Name: Target Molecule Corp
Tel: 781-999-5354 , 18019718960
Fax:
Website: https://www.targetmol.com/
Company Name: HANGZHOU CLAP TECHNOLOGY CO.,LTD
Tel: 86-571-88216897、88216896 , 13588875226
Fax: 86-571-88216895
Website: www.hzclap.com/en
Company Name: InvivoChem
Tel: +1-708-310-1919
Fax: 708-557-7486
Website: https://www.invivochem.com/
Company Name: Amadis Chemical Company Limited
Tel: 0086-571-89925085
Fax: 0086-571-89925065
Website: www.amadischem.com
Company Name: Chengdu Henghui Pharmaceutical Co., Ltd.
Tel: 86-028-89481236 13540674322 15828370308
Fax: 86-028-89481236
Website: www.2hpharm.com
Company Name: Chengdu Henghui Pharm Tec Co. Ltd.  
Tel: 13540674322 15828370308;QQ:2879822141
Fax:028-89481236
Website:www.2hpharm.com
Company Name: Jinan shenlikang chemical technology co. LTD  Gold
Tel:0531-86092839-
Fax:QQ:2425815073
Website:www.chemicalbook.com/showsupplierproductslist1220925/0.htm
Company Name: Shanghai Boyle Chemical Co., Ltd.  
Tel:
Fax:86-21-57758967
Website:www.boylechem.com
Company Name: Chembest Research Laboratories Limited  
Tel:021-20908456-
Fax:021-58180499
Website:http://www.BioChemBest.com
Company Name: Dalian Meilun Biotech Co., Ltd.  
Tel:0411-62910999- ;0411-62910999-
Fax:
Website:www.meilune.com/
Company Name: Haoyuan Chemexpress Co., Ltd.  
Tel:86-21-58998985
Fax:(86) 21-58955996
Website:gb.chemexpress.com.cn
Company Name: Shanghai TaoShu Biochemical Technology Co., Ltd.  
Tel:021-33632979-
Fax:021-33632979
Website:www.tsbiochem.com
Company Name: Jinan WanXiang Chemical Products Co., Ltd  
Tel: ;
Fax:0531-66958526
Website:www.ycpharm.cn
Company Name: AdooQ Bioscience CHINA  
Tel:025-58849295
Fax:025-68650336
Website:http://www.adooq.cn
Tags:1073154-85-4 Related Product Information
1073160-26-5 1297538-32-9 129830-38-2 1257044-40-8 1061353-68-1 871700-17-3 851983-85-2 763113-22-0