| Chemical Properties | Back Directory | [Boiling point ]
255.3±13.0 °C(Predicted) | [density ]
1.216±0.06 g/cm3(Predicted) | [storage temp. ]
Inert atmosphere,Room Temperature | [pka]
4.81±0.10(Predicted) | [Appearance]
Off-white to yellow <27°C Solid,>27°C Liquid |
| Hazard Information | Back Directory | [Synthesis]
General procedure for the synthesis of 7-fluoroisoquinoline from 1-chloro-7-fluoroisoquinoline: 1-chloro-7-fluoroisoquinoline (60 g, 330 mmol) was dissolved in methanol and 6 g of Pd/C catalyst and 53 g (1.3 mol) of sodium hydroxide were added. The reaction was carried out overnight under hydrogen atmosphere. After completion of the reaction, filtration was carried out and the filtrate was collected and dried. Finally, purification by column chromatography (using petroleum ether as eluent) gave 20 g of the target product 7-fluoroisoquinoline. | [References]
[1] Patent: CN108314648, 2018, A. Location in patent: Paragraph 0019; 0083-0084 |
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