| Identification | Back Directory | [Name]
[1R,4S,(+)]-N,2,3,3-Tetramethylbicyclo[2.2.1]heptane-2-amine | [CAS]
107538-05-6 | [Synonyms]
Dexmecamylamine
[1R,4S,(+)]-N,2,3,3-Tetramethylbicyclo[2.2.1]heptane-2-amine
Bicyclo[2.2.1]heptan-2-amine, N,2,3,3-tetramethyl-, (1R,2S,4S)- | [Molecular Formula]
C11H21N | [MDL Number]
MFCD03700730 | [MOL File]
107538-05-6.mol | [Molecular Weight]
167.29 |
| Hazard Information | Back Directory | [Uses]
Dexmecamylamine ((+)-Mecamylamine) is the antagonist for nicotinic acetylcholine receptor (nAChR), that antagonises the α3β4/α4β2/α7/α1β1γδ receptor with IC50 of micromolare levels. Dexmecamylamine exhibits anxiolytic and antidepressant-like activities[1]. | [References]
[1] Yu LF, et al., Recent developments in novel antidepressants targeting α4β2-nicotinic acetylcholine receptors. J Med Chem. 2014 Oct 23;57(20):8204-23. DOI:10.1021/jm401937a |
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