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1082041-20-0

1082041-20-0 Structure

1082041-20-0 Structure
IdentificationBack Directory
[Name]

3-Hydroxy 1H-indazole-5-Methylcarboxylate
[CAS]

1082041-20-0
[Synonyms]

Methyl 3-hydroxy indazole-5-carboxylate
3-Hydroxy 1H-indazole-5-Methylcarboxylate
Methyl 3-hydroxy-1H-indazole-5-carboxylate
methyl 3-oxo-2,3-dihydro-1H-indazole-5-carboxylate
1H-Indazole-5-carboxylic acid, 2,3-dihydro-3-oxo-, methyl ester
[Molecular Formula]

C9H8N2O3
[MDL Number]

MFCD11007794
[MOL File]

1082041-20-0.mol
[Molecular Weight]

192.17
Chemical PropertiesBack Directory
[storage temp. ]

under inert gas (nitrogen or Argon) at 2-8°C
Hazard InformationBack Directory
[Synthesis]

Methanol

67-56-1

3-HYDROXY-5-(1H)INDAZOLE CARBOXYLIC ACID

787580-93-2

3-Hydroxy 1H-indazole-5-Methylcarboxylate

1082041-20-0

3-Oxo-2,3-dihydro-1hydro-indazole-5-carboxylic acid (1.5 g, 8.4 mmol) was suspended in methanol (17 mL). Concentrated hydrochloric acid (3.11 mL, 101 mmol) was added slowly and the reaction mixture was heated to 100 °C and refluxed for 6 hours. After completion of the reaction, the reaction solution was concentrated under reduced pressure to afford the white solid product methyl 3-hydroxy-1H-indazole-5-carboxylate (1.60 g, 99% yield). The product was detected by mass spectrometry (ESI) showing [M + H]+ peak of 193.1; 1H NMR (400 MHz, DMSO-d6, δ) data were as follows: 12.00 (br.s, 1H), 8.35 (s, 1H), 7.83 (dd, J = 8.9,1.7 Hz, 1H), 7.33 (dd, J = 8.9,7.7 Hz, 1H). 3.82 (s, 3H).

[References]

[1] Patent: US2012/108619, 2012, A1. Location in patent: Page/Page column 34
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