| Identification | Back Directory | [Name]
8-Methyl-3,4-dihydroisoquinolin-1(2H)-one | [CAS]
1082041-79-9 | [Synonyms]
8-Methyl-3,4-dihydroisoquinolin-1(2H)-one
8-Methyl-3,4-dihydro-2H-isoquinolin-1-one
1(2H)-Isoquinolinone, 3,4-dihydro-8-methyl- | [Molecular Formula]
C10H11NO | [MDL Number]
MFCD11007915 | [MOL File]
1082041-79-9.mol | [Molecular Weight]
161.2 |
| Chemical Properties | Back Directory | [Boiling point ]
404.3±45.0 °C(Predicted) | [density ]
1.111±0.06 g/cm3(Predicted) | [storage temp. ]
Sealed in dry,Room Temperature | [pka]
14.73±0.20(Predicted) | [Appearance]
White to off-white Solid |
| Hazard Information | Back Directory | [Synthesis]
8-Methylisoquinolin-1(2H)-one (76a, 1 g, 6.29 mmol) was used as raw material and mixed with 10% Pd/C (0.5 g) in methanol (20 mL). The mixture was subjected to hydrogenation reaction under hydrogen (60 psi) atmosphere at 80°C for 48 hours. Upon completion of the reaction, the reaction mixture was filtered and the solid catalyst was washed with methanol (2 x 20 mL). The filtrate was concentrated under vacuum to afford the target product 8-methyl-3,4-dihydroisoquinolin-1(2H)-one (76b, 1 g, ~100% yield) as a gray solid. | [References]
[1] Patent: US2014/179667, 2014, A1. Location in patent: Paragraph 0874; 0876 |
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