| Identification | Back Directory | [Name]
p-iodo-Clonidine (hydrochloride) | [CAS]
108294-57-1 | [Synonyms]
N-(2,6-dichloro-4-iodophenyl)-4,5-dihydro-1H-imidazol-2-amine:hydrochloride | [Molecular Formula]
C9H9Cl3IN3 | [MDL Number]
MFCD30186669 | [MOL File]
108294-57-1.mol | [Molecular Weight]
392.451 |
| Chemical Properties | Back Directory | [storage temp. ]
Store at -20°C | [solubility ]
≤1mg/ml in ethanol;1mg/ml in DMSO;0.25mg/ml in dimethyl formamide | [form ]
crystalline solid |
| Hazard Information | Back Directory | [Uses]
p-Iodoclonidine Hydrochloride is a α2-Adrenergic agonist; and displays a high affinity for the α2-adrenergic receptor. | [Biological Activity]
p-iodo-clonidine (hydrochloride) is a partial agonist of the alpha 2-adrenergic receptor [1].the adrenergic receptors are g protein-coupled receptors that are targets of the catecholamines, especially norepinephrine and epinephrine. there are two main groups of adrenergic receptors: α receptors and β receptors. α2-adrenergic receptor is a gi coupled receptor, which causes a decrease in neurotransmitter release, as well as a decrease of camp activity resulting in smooth muscle contraction [1].p-iodo-clonidine (hydrochloride) is a partial agonist of the alpha 2-adrenergic receptor. clonidine is an antihypertensive α2-adrenergic receptor agonist. pic had minimal agonist activity in inhibiting adenylate cyclase in platelet membranes through α2-adrenergic receptor, but it increased platelet aggregation induced by adp with ec50 value of 1.5 μm. pic also inhibited epinephrine-induced aggregation with ic50 value of 5.1 μm. pic competed for [3h]bromoxidine binding with ki value of 1.0 nm. pic bound to the alpha 2b-ar in ng-10815 cell membranes with kd value of 0.5 +/- 0.1 nm [1]. | [References]
[1]. gerhardt ma, wade sm, neubig rr. p-[125i]iodoclonidine is a partial agonist at the alpha 2-adrenergic receptor. mol pharmacol. 1990 aug;38(2):214-21. |
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| Company Name: |
Energy Chemical
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| Telephone: |
400-0056266 |
| Website: |
www.energy-chemical.com |
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