| Identification | Back Directory | [Name]
PYR-GLN-ARG-LEU-GLY-ASN-GLN-TRP-ALA-VAL-GLY-D-PHE-LEU-MET-NH2 | [CAS]
108437-87-2 | [Synonyms]
12-Phe-bombesin
bombesin, Phe(12)-
[D-PHE12]-BOMBESIN
PYR-QRLGNQWAVGFLM-NH2
Bombesin, 12-D-phenylalanine
Bombesin, phenylalanine(12)-
M.W. 1629.90 C74H112N22O18S
GLP-GLN-ARG-LEU-GLY-ASN-GLN-TRP-ALA-VAL-GLY-DPHE-LEU-MET-NH2
PYR-GLN-ARG-LEU-GLY-ASN-GLN-TRP-ALA-VAL-GLY-D-PHE-LEU-MET-NH2
PGLU-GLN-ARG-LEU-GLY-ASN-GLN-TRP-ALA-VAL-GLY-D-PHE-LEU-MET-NH2
GLP-GLN-ARG-LEU-GLY-ASN-GLN-TRP-ALA-VAL-GLY-DPHE-LEU-MET-NH2: GLP-QRLGNQWAVG-DF-LM-NH2 | [Molecular Formula]
C74H112N22O18S | [MDL Number]
MFCD00076255 | [MOL File]
108437-87-2.mol | [Molecular Weight]
1629.88 |
| Chemical Properties | Back Directory | [density ]
1.46±0.1 g/cm3(Predicted) | [storage temp. ]
-15°C
| [form ]
Solid | [pka]
13.04±0.46(Predicted) | [Water Solubility ]
Soluble to 1 mg/ml in water | [Sequence]
{Pyr}-Gln-Arg-Leu-Gly-Asn-Gln-Trp-Ala-Val-Gly-{d-Phe}-Leu-Met-NH2 |
| Hazard Information | Back Directory | [Uses]
[D-Phe12]-Bombesin is a derivative of Bombesin (HY-P0195) and an antagonist for bombesin receptor with Ki of 4.7 μM. [D-Phe12]-Bombesin inhibits the Bombesin (HY-P0195)-induced amylase release, with IC50 of 4 μM[1]. | [References]
[1] Heinz-Erian P, et al., [D-Phe12]bombesin analogues: a new class of bombesin receptor antagonists. Am J Physiol. 1987 Mar;252(3 Pt 1):G439-42. DOI:10.1152/ajpgi.1987.252.3.G439 |
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