| Identification | Back Directory | [Name]
Prolyl Endopeptidase Inhibitor II | [CAS]
108708-25-4 | [Synonyms]
1-Pyrrolidinecarboxylic acid, 2-[(2-formyl-1-pyrrolidinyl)carbonyl]-, phenylmethyl ester | [Molecular Formula]
C18H22N2O4 | [MOL File]
108708-25-4.mol | [Molecular Weight]
330.38 |
| Chemical Properties | Back Directory | [Boiling point ]
529.1±50.0 °C(Predicted) | [density ]
1.312±0.06 g/cm3(Predicted) | [storage temp. ]
-20°C | [solubility ]
DMSO: 10mg/mL
DMF: soluble
ethyl acetate: soluble | [form ]
oil | [pka]
-2.43±0.40(Predicted) | [color ]
colorless to off-white | [Sequence]
Z-Pro-Pro-CHO |
| Hazard Information | Back Directory | [Uses]
Z-Pro-Pro-CHO is a prolyl oligopeptidase inhibitor (IC50: 0.16 μM and 0.01 μM for human and Schistosoma Mansoni prolyl oligopeptidase respectively)[1]. | [Biological Activity]
Cell permeable: yes''Primary Target
Mouse brain prolylendooeotidase''Product does not compete with ATP.''Reversible: no''Target Ki: 350 pM and 500 pM for mouse brain and human brain prolyl endopeptidaserespectively | [IC 50]
Schistosome | [References]
[1] Fajtová P, et al. Prolyl Oligopeptidase from the Blood Fluke Schistosoma mansoni: From Functional Analysis to Anti-schistosomal Inhibitors. PLoS Negl Trop Dis. 2015 Jun 3;9(6):e0003827. DOI:10.1371/journal.pntd.0003827 |
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| Company Name: |
Merck KGaA
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| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
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