| Identification | Back Directory | [Name]
2,5-Dimethyl-4-sulfamoylfuran-3-carboxylic Acid | [CAS]
1087784-71-1 | [Synonyms]
Metallo β-lactamase ligand 1
2,5-Dimethyl-4-sulfamoylfuran-3-carboxylic Acid
3-Furancarboxylic acid, 4-(aminosulfonyl)-2,5-dimethyl-
Bacterial,β-lactamase,sulfamoyl,Metallo βlactamase ligand 1,Metallo β-lactamase ligand 1,Inhibitor,antibacterial,antibiotics,inhibit,carboxyl,Metallo β lactamase ligand 1 | [Molecular Formula]
C7H9NO5S | [MDL Number]
MFCD11505466 | [MOL File]
1087784-71-1.mol | [Molecular Weight]
219.22 |
| Chemical Properties | Back Directory | [Boiling point ]
442.7±55.0 °C(Predicted) | [density ]
1.498±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
3.93±0.46(Predicted) | [color ]
Light yellow to light brown |
| Hazard Information | Back Directory | [Uses]
Metallo-beta-lactamase ligand 1 is a class B β-lactamase inhibitor with antibacterial activity extracted from patent WO2019221122A1, compound A[1]. | [in vivo]
After infecting mice with an experimental strain (E. coli strain into which a plasmid encoding class B β-lactamase (IMP-1) is introduced), Metallo-beta-lactamase ligand 1 (compound A; 100 mg/kg; intraperitoneal injection) is administered, and life and death are observed. Administration of Metallo-beta-lactamase ligand 1 (compound A) significantly improves the survival rate[1]. | [References]
[1] Arakawa, Yoshichika, et al.β-LACTAMASE INHIBITOR. WO2019221122A1. |
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