| Identification | Back Directory | [Name]
LUMIFLAVINE | [CAS]
1088-56-8 | [Synonyms]
Lumiflavin
LUMIFLAVINE
Lumilactoflavin
Lumiflavin (III)
Riboflavin EP Impurity A
7,8,10-TRIMETHYLISOALLOXAZINE
Riboflavin Impurity 3 (Lumiflavine)
7,8,10-trimethylbenzo[g]pteridine-2,4-dione
7,8,10-trimethylbenzo[g]pteridine-2,4-quinone
(3h,10h)-dione,7,8,10-trimethyl-benzo(g)pteridine-4
7,8,10-TRIMETHYLBENZO[G]PTERIDINE-2,4(3H,10H)-DIONE
4-hydroxy-7,8,10-triMethylbenzo[g]pteridin-2(10H)-one
7,8-Dimethyl-10-methylbenzo[g]pteridine-2,4(3H,10H)-dione
7,8,10-Trimethyl-2,3,4,10-tetrahydrobenzo[g]pteridine-2,4-dione
7,8,10-Trimethyl-2,3,4,10-tetrahydropyrimido[4,5-b]quinoxaline-2,4-dione
7,8,10-Trimethylbenzo[g]pteridine-2,4(3H,10H)-dione, 7,8,10-Trimethylisoalloxazine
Lumiflavine,7,8,10-Trimethylbenzo[g]pteridine-2,4(3H,10H)-dione, 7,8,10-Trimethylisoalloxazine | [EINECS(EC#)]
214-125-5 | [Molecular Formula]
C13H12N4O2 | [MDL Number]
MFCD00042742 | [MOL File]
1088-56-8.mol | [Molecular Weight]
256.26 |
| Chemical Properties | Back Directory | [Appearance]
deep yellow powder | [Melting point ]
320°; mp 330° | [storage temp. ]
2-8°C
| [solubility ]
Methanol (Very Slightly, Heated, Sonicated), Trifluoroacetic Acid (Very Slightly | [density ]
1.48 g/cm3 | [form ]
powder
| [pka]
10.05±0.70(Predicted) | [color ]
Dark Yellow to Dark Green | [Stability:]
Stable. Incompatible with strong oxidizing agents. | [Merck ]
13,5621 |
| Hazard Information | Back Directory | [Chemical Properties]
deep yellow powder | [Uses]
Lumiflavin is a toxic photolysis product of vitamin B2 (R415000). | [Definition]
ChEBI: Lumiflavin is a compound showing yellow-green fluorescence, formed by a photolysis of riboflavin in alkaline solution. | [in vivo]
Lumiflavin (8 mg/kg, i.p., once a day for 25 days) has a synergistic cytotoxic effect on an ovarian cancer nude mice model by enhancing the DNA‐damage response and increasing the apoptotic protein expression[2].
Lumiflavin (4-16 mg/kg, s.c., once a day for 25 days) combined with DDP reduces tumor weight and inhibits tumor growth[3].
| Animal Model: | Nude mice[3] | | Dosage: | 4-16 mg/kg | | Administration: | s.c., once a day for 25 days | | Result: | Reduced tumor weight and inhibited tumor growth curve combined with DDP in a dose-dependent manner. |
| [storage]
Store at -20°C | [Purification Methods]
Lumiflavin forms orange crystals upon recrystallisation from 12% aqueous AcOH, or from formic acid. It sublimes at high vacuum. It is freely soluble in CHCl3, but not very soluble in H2O and most organic solvents. In H2O and CHCl3 solution it has a green fluorescence. UV has max at 269, 355 and 445nm ( 38,800, 11,700 and 11,800, respectively) in 0.1N NaOH and 264, 373 and 440nm ( 34,700, 11,400 and 10,400, respectively) in 0.1N HCl, while the UV in CHCl3 has max at 270, 312, 341, 360, 420, 445 and 470nm. [Hemmerich et al. Helv Chim Acta 39 1242 1956, Holiday & Stern Chem Ber 67 1352 1834, Yoneda et al. Chem Pharm Bull Jpn 20 1832 1972, Birch & Moye J Chem Soc 2622 1958, Fluorescence: Kuhn & Moruzzi Chem Ber 67 888 1934, Beilstein 26 III/IV 2539.] |
|
| Company Name: |
J & K SCIENTIFIC LTD.
|
| Telephone: |
18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
| Company Name: |
TOSUN PHARM
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| Telephone: |
020-66392521-118 18922260391 |
| Website: |
www.toref.cn/ |
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