| Identification | Back Directory | [Name]
AC-LEVD-AFC | [CAS]
1092077-23-0 | [Synonyms]
AC-LEVD-AFC
AC-LEU-GLU-VAL-ASP-AFC
CASPASE-4 SUBSTRATE (AFC)
CASPASE-4 SUBSTRATE (CHROMOGENIC)
CASPASE-4 SUBSTRATE II, FLUOROGENIC
CASPASE 4 (ICH-2) SUBSTRATE 1F, FLUOROGENIC
AC-LEU-GLU-VAL-ASP-7-AMINO-4-TRIFLUORO-METHYLCOUMARIN
N-ACETYL-LEU-GLU-VAL-ASP-7-AMIDO-4-TRIFLUOROMETHYLCOUMARIN
L-α-Asparagine, N-acetyl-L-leucyl-L-α-glutamyl-L-valyl-N-[2-oxo-4-(trifluoromethyl)-2H-1-benzopyran-7-yl]- | [Molecular Formula]
C32H40F3N5O11 | [MDL Number]
MFCD01862605 | [MOL File]
1092077-23-0.mol | [Molecular Weight]
727.68 |
| Hazard Information | Back Directory | [Description]
Ac-LEVD-AFC is a fluorogenic substrate for caspase-4. Upon enzymatic cleavage by caspase-4, 7-amino-4-trifluoromethylcoumarin (AFC) is released and its fluorescence can be used to quantify caspase-4 activity. AFC displays excitation/emission maxima of 400/505 nm, respectively. | [Uses]
Ac-LEVD-AFC is capspase-4 fluorogenic substrate peptide that can be used for caspase-4 activity studies[1]. | [storage]
Store at -20°C | [References]
[1] Pallett MA, et al. Bacterial virulence factor inhibits caspase-4/11 activation in intestinal epithelial cells. Mucosal Immunol. 2017 May;10(3):602-612. DOI:10.1038/mi.2016.77 |
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