ChemicalBook--->CAS DataBase List--->109376-05-8

109376-05-8

109376-05-8 Structure

109376-05-8 Structure
IdentificationBack Directory
[Synonyms]

BOC-QRR-AMC
BOC-GLN-ARG-ARG-MCA
Boc-Gln-Arg-Arg-AMC
BOC-GLN-ARG-ARG-AMC ACOH
BOC-GLN-ARG-ARG-AMC ACETATE SALT
Boc-Gln-Arg-Arg-AMC (I-1655.0025)
N-T-boc-gln-arg-arg 7-amido-4-*methylcoumarin ace
N-T-BOC-GLN-ARG-ARG 7-AMIDO-4-*METHYLCOUMARIN ACETAT
N-tert-BOC-Gln-Arg-Arg 7-amido-4-methylcoumarin acetate
Boc-Gln-Arg-Arg-7-amido-4-methylcoumarin acetate salt
T-BUTYLOXYCARBONYL-L-GLUTAMINYL-L-ARGINYL-L-ARGININE 4-METHYLCOUMARYL-7-AMIDE
[MOL File]

109376-05-8.mol
Chemical PropertiesBack Directory
[density ]

1.43±0.1 g/cm3(Predicted)
[pka]

11.17±0.46(Predicted)
[Sequence]

{Boc}-Gln-Arg-Arg-{AMC}
Hazard InformationBack Directory
[Uses]

Boc-Gln-Arg-Arg-AMC is a fluorogenic substrate for the determination of protease activity. Boc-Gln-Arg-Arg-AMC undergoes hydrolysis and releases the fluorescent product 7-amino-4-methylcoumarin (AMC). AMC is fluorescent under UV light and can emit a fluorescent signal[1].
[References]

[1] Tervonen TA, et, al. Deregulated hepsin protease activity confers oncogenicity by concomitantly augmenting HGF/MET signalling and disrupting epithelial cohesion. Oncogene. 2016 Apr 7;35(14):1832-46. DOI:10.1038/onc.2015.248
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