Identification | Back Directory | [Name]
1H-Pyrazole-4-carboxamide, 5-amino-N-[(2R)-2-[[(2,6-dichlorobenzoyl)ethylamino]methyl]-3,3,3-trifluoro-2-hydroxypropyl]-1-(4-fluorophenyl)- | [CAS]
1094607-80-3 | [Synonyms]
(R)-GSK866 1H-Pyrazole-4-carboxamide, 5-amino-N-[(2R)-2-[[(2,6-dichlorobenzoyl)ethylamino]methyl]-3,3,3-trifluoro-2-hydroxypropyl]-1-(4-fluorophenyl)- | [Molecular Formula]
C23H21Cl2F4N5O3 | [MOL File]
1094607-80-3.mol | [Molecular Weight]
562.34 |
Chemical Properties | Back Directory | [Boiling point ]
761.3±60.0 °C(predicted) | [density ]
1.49±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted) | [form ]
Solid | [pka]
9.13±0.46(predicted) | [color ]
White to off-white |
Hazard Information | Back Directory | [Uses]
(R)-GSK866 is the (R)-enantiomer of GSK866 (HY-157294). GSK866 is a selective agonist for glucocorticoid receptor with an IC50 of 4.6 nM[1]. | [References]
[1] Chandra S Chirumamilla, et al. Selective Glucocorticoid Receptor Properties of GSK866 Analogs with Cysteine Reactive Warheads. Front Immunol. 2017 Nov 1:8:1324. DOI:10.3389/fimmu.2017.01324 |
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Biorbyt Ltd.
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+44 (0)1223 859 353 |
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http://www.biorbyt.com |
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