| Identification | Back Directory | [Name]
4-(2-fluorophenyl)-2,3-dihydro-1,3-thiazol-2-one | [CAS]
1095051-79-8 | [Synonyms]
2(3H)-Thiazolone, 4-(2-fluorophenyl)-
4-(2-fluorophenyl)-2,3-dihydro-1,3-thiazol-2-one
4(2fluorophenyl)2,3dihydro1,3thiazol2one,4 (2 fluorophenyl) 2,3 dihydro 1,3 thiazol 2 one | [Molecular Formula]
C9H6FNOS | [MDL Number]
MFCD09746485 | [MOL File]
1095051-79-8.mol | [Molecular Weight]
195.21 |
| Hazard Information | Back Directory | [Uses]
BRD4 Inhibitor-37 is a compound with anticancer activity that has inhibitory activity against BRD4. BRD4 Inhibitor-37 has an IC50 of approximately 0.05-0.1 μM in binding assays and shows a GI50 of 0.1-0.3 μM in cell-based assays. The effect of BRD4 Inhibitor-37 on c-Myc, a downstream protein of BRD4, has been validated, demonstrating its ability to intervene in this signaling pathway. BRD4 Inhibitor-37 exhibits selectivity among five different bromodomain proteins, enhancing its potential as a BET protein inhibitor[1]. | [References]
[1] Fragment-based drug discovery of 2-thiazolidinones as BRD4 inhibitors: 2. Structure-based optimization |
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