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1099592-35-4

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1099592-35-4 Structure

1099592-35-4 Structure
IdentificationBack Directory
[Name]

2-hydroxy-N'-[(E)-(2-hydroxynaphthalen-1-yl)methylidene]benzohydrazide
[CAS]

1099592-35-4
[Synonyms]

NASH
Naphthyl salicylic acyl hydrazone
(E)-2-Hydroxy-N'-((2-hydroxynaphthalen-1-yl)methylene)benzohydrazide
DNA/RNA Synthesis,HCT116,MDA-231,Panc1,Inhibitor,NSAH,inhibit,S-phase
2-hydroxy-N'-[(E)-(2-hydroxynaphthalen-1-yl)methylidene]benzohydrazide
Benzoic acid, 2-hydroxy-, (2E)-2-[(2-hydroxy-1-naphthalenyl)methylene]hydrazide
[Molecular Formula]

C18H14N2O3
[MDL Number]

MFCD00196698
[MOL File]

1099592-35-4.mol
[Molecular Weight]

306.32
Chemical PropertiesBack Directory
[storage temp. ]

Store at -20°C
[solubility ]

DMSO : 62.5 mg/mL (204.03 mM; Need ultrasonic)
[form ]

Solid
[color ]

Light yellow to yellow
[InChI]

InChI=1S/C18H14N2O3/c21-16-8-4-3-7-14(16)18(23)20-19-11-15-13-6-2-1-5-12(13)9-10-17(15)22/h1-11,21-22H,(H,20,23)/b19-11+
[InChIKey]

ZZSJOLDICPVVAV-YBFXNURJSA-N
[SMILES]

C(N/N=C/C1=C2C(C=CC=C2)=CC=C1O)(=O)C1=CC=CC=C1O
Safety DataBack Directory
[Symbol(GHS) ]

Exclamation Mark (GHS07)
GHS07
[Signal word ]

Warning
[Hazard statements ]

H302-H315-H319-H335
[Precautionary statements ]

P261-P280-P301+P312-P302+P352-P305+P351+P338
[WGK Germany ]

WGK 3
[Storage Class]

11 - Combustible Solids
Hazard InformationBack Directory
[Uses]

NSAH is a reversible and competitive nonnucleoside ribonucleotide reductase (RR) inhibitor, with cell-free IC50 of 32 μM and cell-based IC50 of ~250 nM, respectively[1].
[Biological Activity]

NSAH is a cell penetrantpotent and selective nonnucleoside reversible inhibitor of large subunit (hRRM1) of hRR (human ribonucleotide reductase). NSAH binds to catalytic site of hRRM1. It inhibits hRR in cells. NSAH exhibit potent cytotoxicity toward cancer cellswhile demonstrated very moderate toxicity against normal blood progenitor cells.
[References]

[1] Md Faiz Ahmad, et al. Potent competitive inhibition of human ribonucleotide reductase by a nonnucleoside small molecule. Proc Natl Acad Sci U S A. 2017 Aug 1;114(31):8241-8246. DOI:10.1073/pnas.1620220114
Spectrum DetailBack Directory
[Spectrum Detail]

2-hydroxy-N'-[(E)-(2-hydroxynaphthalen-1-yl)methylidene]benzohydrazide(1099592-35-4)1HNMR
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