| Identification | Back Directory | [Name]
Flavomycin | [CAS]
11015-37-5 | [Synonyms]
menomycin
MOENOMYCIN
FLAVOMYCIN
BAMBERMYCIN
Flavomycine
Moenomycine
Bambermycine
BAMBERMYCINS
moenomycin a
Flavomycin Premix
flavophospholipol
MoenoMycin coMplex
BAMBERMYCIN(FLAVOMYCIN)
Bambermycins, Moenomycin
Flavomycin (8 %, Mixture of congeners)
(2S,3S,4R,5R,6R)-5-(((2S,3R,4R,5S,6R)-3-acetaMido-5-(((2S,3R,4R,5S)-3-acetaMido-4-hydroxy-6-Methyl-5-(((2R,3R,4S,5R,6S)-3,4,5-trihydroxy-6-((2-hydroxy-5-oxocyclopent-1-en-1-yl)carbaMoyl)tetrahydro-2H-pyran-2-yl)oxy)tetrahydro-2H-pyran-2-yl)oxy)-4-hydroxy- | [EINECS(EC#)]
234-246-7 | [Molecular Formula]
C69H107N4O35P | [MDL Number]
MFCD01742468 | [MOL File]
11015-37-5.mol | [Molecular Weight]
1583.57 |
| Hazard Information | Back Directory | [Usage]
Moenomycin complex is a mixture of five major components, A, A12, C1, C3 and C4, isolated from several strains of Streptomyces in the 1960s. Moenomycins are high molecular weight phosphoglycolipids with potent antibiotic activity used in animal health. Moenomycins are the only antibiotic known to selectively inhibit the transglycosylation step catalysed by penicillin-binding protein 1b. | [Description]
Moenomycin complex is a mixture of moenomycins A, A12, C1, C3 and C4, which are antibiotics isolated from several strains of Streptomyces that directly inhibit bacterial peptidoglycan glycosyltransferases.1 The minimal inhibitory concentration of moenomycin A against various Gram-positive bacteria ranges from 1-100 nM.1 | [Chemical Properties]
Colorless, amorphous salt, a stable complex composed of four chemically similar microbial active substances, containing 1.96% phosphorus. A weak acid. Soluble in water and low-molecular-weight alcohols, insoluble in other organic solvents. | [Uses]
Moenomycin complex is a mixture of five major components, A, A12, C1, C3 and C4, isolated from several strains of Streptomyces in the 1960s. Moenomycins are high molecular weight phosphoglycolipids with potent antibiotic activity used in animal health. Moenomycins are the only antibiotic known to selectively inhibit the transglycosylation step catalysed by penicillin-binding protein 1b. | [Definition]
ChEBI: A glycophospholipid antibiotic compound with the lipid portion conjugated to a pentasaccharide fraction via a phosphate linkage. | [Brand name]
Flavomycin (Hoechst-Roussel). | [General Description]
Flavophospholipol, formerly called moenomycin, was found in the culture broth of Streptomyces bambergiensis by Hoechst in 1955. This drug is called bambermycin by INN and in the United States. It shows strong activity against gram-positive bacteria and weak activity against gram-negative bacteria. Flavophospholipol has been used as a feed additive for growth promotion in poultry. | [storage]
Store at -20°C, protect from light | [References]
[1] OSTASH B, WALKER S. Moenomycin family antibiotics: chemical synthesis, biosynthesis, and biological activity[J]. Natural Product Reports, 2010, 11: 1594-1617. DOI: 10.1039/c001461n |
| Safety Data | Back Directory | [Hazard statements ]
H413 | [Risk Statements ]
53 | [RIDADR ]
UN 3077 9 / PGIII | [WGK Germany ]
1 | [RTECS ]
QA3020000 | [Safety Profile]
Poison by intravenous
route. Moderately toxic by subcutaneous
route. | [Toxicity]
LD50 in mice (mg/kg): >2000 orally, s.c. and i.p.; 1400 i.v. (Lindner, Wallhuser) |
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