| Identification | Back Directory | [Name]
taxamairin B | [CAS]
110300-77-1 | [Synonyms]
taxamairin B
1H-Dibenzo[a,d]cycloheptene-2,10-dione, 6,7-dimethoxy-1,1-dimethyl-8-(1-methylethyl)- | [Molecular Formula]
C22H24O4 | [MOL File]
110300-77-1.mol | [Molecular Weight]
352.42 |
| Hazard Information | Back Directory | [Uses]
Taxamairin B is a potent anti-inflammatory agent. Taxamairin B decreases proinflammatory cytokines (TNF-α, IL-1β and IL-6) expression and the production of NO and ROS in LPS-induced RAW264.7 cells. Taxamairin B exhibits significant
protective effects in LPS-induced acute lung injury in mice[1][2]. | [References]
[1] Liu M, et al. Rapid access to icetexane diterpenes: Their protective effects against lipopolysaccharides-induced acute lung injury via PI3K/AKT/NF-κB axis in macrophages. Eur J Med Chem. 2023 Nov 15;260:115769. DOI:10.1016/j.ejmech.2023.115769
[2] Liang JY, et al. Two new antineoplastic diterpenes from Taxus mairei. Chem Pharm Bull (Tokyo). 1987 Jun;35(6):2613-4. DOI:10.1248/cpb.35.2613 |
|
|