| Identification | Back Directory | [Name]
2-benzyl-5-chloro-1,2,3,4-tetrahydro-2,6-naphthyridine | [CAS]
1104027-46-4 | [Synonyms]
2-benzyl-5-chloro-3,4-dihydro-1H-2,6-naphthyridine 2-benzyl-5-chloro-1,2,3,4-tetrahydro-2,6-naphthyridine 5-Chloro-1,2,3,4-tetrahydro-2-(benzyl)-2,6-naphthyridine 5-Chloro-1,2,3,4-tetrahydro-2-(phenylmethyl)-2,6-naphthyridine 2,6-Naphthyridine, 5-chloro-1,2,3,4-tetrahydro-2-(phenylmethyl)- 2-benzyl-5-chloro-1,2,3,4-tetrahydro-2,6-naphthyridine hydrochloride 2,6-Naphthyridine-2(1H)-carboxylic acid, 5-chloro-3,4-dihydro-, 1,1-dimethylethyl ester | [Molecular Formula]
C15H15ClN2 | [MDL Number]
MFCD11846202 | [MOL File]
1104027-46-4.mol | [Molecular Weight]
258.746 |
| Chemical Properties | Back Directory | [Boiling point ]
377.5±42.0 °C(Predicted) | [density ]
1.227 | [storage temp. ]
under inert gas (nitrogen or Argon) at 2-8°C | [pka]
5.38±0.20(Predicted) |
| Hazard Information | Back Directory | [Uses]
5-Chloro-1,?2,?3,?4-tetrahydro-?2-?(phenylmethyl)?-2,?6-naphthyridine is an intermediate used to prepare substituted naphthyridines as FAAH modulators useful in prevention and treatment of FAAH-mediated diseases. | [Synthesis]
A round bottom flask was charged with 6-benzyl-5,6,7,8-tetrahydro-2,6-naphthyridin-1-ol (7 g, 29 mmol) and phosphorochloridic acid {LeonidChemicals, India; add 80 mL) and heated to reflux for 16 hours to monitor the progress of the reaction by TLC. Upon c |
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