ChemicalBook--->CAS DataBase List--->1104546-89-5

1104546-89-5

Request For Quotation
1104546-89-5 Structure

1104546-89-5 Structure
IdentificationBack Directory
[Name]

4-[(1-Methyl-1H-pyrrol-2-yl)methylene]-1,3(2H,4H)-isoquinolinedione
[CAS]

1104546-89-5
[Synonyms]

RT-017290
BYK 204165
PARP Inhibitor XIV
BYK204165 >=98% (HPLC)
4-(1-methyl-1H-pyrrol-2-ylmethylene)-4H-isoquinolin-1,3-dione
4-(1-Methyl-1H-pyrrol-2-ylmethylene)-4H-isoquinoline-1,3-dione
4-[(1-Methyl-1H-pyrrol-2-yl)methylene]-1,3(2H,4H)-isoquinolinedione
1,3(2H,4H)-Isoquinolinedione, 4-[(1-methyl-1H-pyrrol-2-yl)methylene]-
[Molecular Formula]

C15H12N2O2
[MDL Number]

MFCD12912397
[MOL File]

1104546-89-5.mol
[Molecular Weight]

252.27
Chemical PropertiesBack Directory
[Boiling point ]

492.5±45.0 °C(Predicted)
[density ]

1.27±0.1 g/cm3(Predicted)
[storage temp. ]

2-8°C
[solubility ]

DMSO: >20mg/mL
[form ]

powder
[pka]

9.30±0.20(Predicted)
[color ]

yellow
[InChI]

1S/C15H12N2O2/c1-17-8-4-5-10(17)9-13-11-6-2-3-7-12(11)14(18)16-15(13)19/h2-9H,1H3,(H,16,18,19)/b13-9-
[InChIKey]

BTYSIDSTHDDAJW-LCYFTJDESA-N
[SMILES]

Cn1cccc1\C=C2/C(=O)NC(=O)c3ccccc23
Safety DataBack Directory
[Hazard Codes ]

Xi
[Risk Statements ]

43
[Safety Statements ]

36/37
[WGK Germany ]

3
[Storage Class]

11 - Combustible Solids
[Hazard Classifications]

Skin Sens. 1
Hazard InformationBack Directory
[Uses]

BYK 204165 is an inhibitor of the poly(ADP-?ribose) polymerase (PARP), and it is 100-fold more selective for PARP-1.
[Biochem/physiol Actions]

BYK204165 is a potent and selective inhibitor of poly(ADP-ribose) polymerase 1 (PARP1). It is 100-fold selective for PARP-1 over PARP-2.
[in vivo]

BYK204165 is not investigated in vivo because of its short half-time (t1/2) of 23 min measured at rat microsomes in vitro[1].

[IC 50]

hPARP-1: 7.35 (pIC50); mPARP-2: 5.38 (pIC50)
Spectrum DetailBack Directory
[Spectrum Detail]

4-[(1-Methyl-1H-pyrrol-2-yl)methylene]-1,3(2H,4H)-isoquinolinedione(1104546-89-5)1HNMR
1104546-89-5 suppliers list
Company Name: 3B Pharmachem (Wuhan) International Co.,Ltd.  
Telephone: 18930552037
Website: www.chemicalbook.com/showsupplierproductslist13285/0_en.htm
Company Name: Bide Pharmatech Ltd.  
Telephone: 400-164-7117 18317119277
Website: www.bidepharm.com
Company Name: Sigma-Aldrich  
Telephone: 021-61415566 800-8193336
Website: https://www.sigmaaldrich.cn
Company Name: Shanghai YuanYe Biotechnology Co., Ltd.  
Telephone: 15026964105
Website: www.shyuanye.com
Company Name: Tianjin Kailiqi Biotechnology Co., Ltd.  
Telephone: 15076683720
Website: http://www.cw-bio.com
Company Name: HANGZHOU CLAP TECHNOLOGY CO.,LTD  
Telephone: 86-571-88216897,88216896 13588875226
Website: www.hzclap.com/en
Company Name: Henan Weituxi Chemical Technology Co., Ltd.  
Telephone: 0371-63284658 18135795563
Website: https://www.chemicalbook.com/supplier/15004346/
Company Name: Jinan ponder chemical co. LTD  
Telephone: 0531-0000
Website: www.chemicalbook.com/ShowSupplierProductsList546697/0_EN.htm
Company Name: ChemeGen(Shanghai) Biotechnology Co.,Ltd.  
Telephone: 18818260767
Website: http://www.chemegen.com
Company Name: Energy Chemical  
Telephone: 400-0056266
Website: www.energy-chemical.com
Company Name: MedBioPharmaceutical Technology Inc  
Telephone: 021-69568360 18916172912
Website: http://www.med-bio.cn/
Company Name: Jinan Jiuli Biotechnology Co. , Ltd.  
Telephone: 15865264761
Website: www.chemicalbook.com/ShowSupplierProductsList89365/0_EN.htm
Company Name: Beijing Jin Ming Biotechnology Co., Ltd.  
Telephone: 010-60605840
Website: http://www.jm-bio.com/
Company Name: Hefei Mokai Pharmaceutical Technology Co., Ltd  
Telephone: 18130062233
Website: www.yxjchem.com/
Company Name: Bide Pharmatech Ltd.  
Telephone: 400-1647117 13681763483
Website: https://www.bidepharm.com/
Company Name: InvivoChem  
Telephone: 13549236410
Website: https://www.invivochem.cn/
Company Name: TargetMol Chemicals Inc.  
Telephone: 4008200310 15002144251
Website: https://www.targetmol.cn/
Company Name: Aikon International Limited  
Telephone: 17714375163
Website: www.aikonchem.com
Tags:1104546-89-5 Related Product Information
6336-34-1 328543-09-5 1825345-33-2 1140964-99-3 2337386-47-5