| Identification | Back Directory | [Name]
OLIGOMYCIN C | [CAS]
11052-72-5 | [Synonyms]
Oligmycin C
OLIGOMYCIN C
12-Deoxyoligomycin A
Oligomycin A, 12-deoxy-
OLIGOMYCIN C, STREPTOMYCES DIASTATOCHROMOGENES
Spiro[2,26-dioxabicyclo[23.3.1]nonacosa-4,18,20-triene-27,2'-[2H]pyran]-3,9,13-trione, 22-ethyl-3',4',5',6'-tetrahydro-7,11,15-trihydroxy-6'-[(2R)-2-hydroxypropyl]-5',6,8,10,12,14,16,28,29-nonamethyl-, (1R,2'R,4E,5'S,6S,6'S,7R,8S,10R,11S,12S,14S,15S,16R,18E,20E,22R,25S,28S,29R)- | [EINECS(EC#)]
234-276-0 | [Molecular Formula]
C45H74O10 | [MDL Number]
MFCD00043231 | [MOL File]
11052-72-5.mol | [Molecular Weight]
775.06 |
| Chemical Properties | Back Directory | [Boiling point ]
876.2±65.0 °C(Predicted) | [density ]
1.091 g/cm3 | [storage temp. ]
−20°C | [solubility ]
Soluble in DMSO | [form ]
White to off-white powder. | [pka]
13.49±0.70(Predicted) | [Merck ]
13,6902 |
| Safety Data | Back Directory | [Hazard Codes ]
Xn | [Risk Statements ]
22 | [RIDADR ]
2811 | [RTECS ]
RK3335000 | [HazardClass ]
6.1(b) | [PackingGroup ]
III | [HS Code ]
2941900000 | [Toxicity]
LD50 ipr-mus: 8300 mg/kg JACSAT 80,6092,1958 |
| Hazard Information | Back Directory | [Description]
Oligomycins are macrolides created by Streptomyces species that can be toxic to other organisms. Different oligomycin isomers are highly specific for the disruption of mitochondrial metabolism. Oligomycin C is a minor component of the oligomycin complex that acts as an inhibitor of the mitochondrial F1FO-ATP synthase. Inhibition of the ATP synthase by oligomycins leads to cell death. | [Uses]
Oligomycin C, a minor component of the oligomycin complex isolated from selected strains of Streptomyces, is an inhibitor of mitochondrial F1F0-ATPase. It makes cells more susceptible to cell death, and also leads to a switch in the death mode from apoptosis to necrosis. | [Safety Profile]
A poison by intraperitoneal route.When heated to decomposition it emits acrid smoke andirritating vapors | [References]
[1]. yang p w, li m g, zhao j y, et al. oligomycins a and c, major secondary metabolites isolated from the newly isolated strain streptomyces diastaticus[j]. folia microbiologica, 2010, 55(1): 10-16.
[2]. marton a, mihalik r, bratincsák a, et al. apoptotic cell death induced by inhibitors of energy conservation[j]. european journal of biochemistry, 1997, 250(2): 467-475. |
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