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110880-53-0

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110880-53-0 Structure

110880-53-0 Structure
IdentificationBack Directory
[Name]

(N-ME-PHE7)-NEUROKININ B
[CAS]

110880-53-0
[Synonyms]

L-Methioninamide, L-α-aspartyl-L-methionyl-L-histidyl-L-α-aspartyl-L-phenylalanyl-L-phenylalanyl-N-methyl-L-phenylalanylglycyl-L-leucyl-
[Molecular Formula]

C60H81N13O14S2
[MDL Number]

MFCD18782503
[MOL File]

110880-53-0.mol
[Molecular Weight]

1272.49
Chemical PropertiesBack Directory
[form ]

Solid
[color ]

White to off-white
[Sequence]

Asp-Met-His-Asp-Phe-Phe-{MePhe}-Gly-Leu-Met-NH2
Hazard InformationBack Directory
[Uses]

[MePhe7]-Neurokinin B is an neurokinin NK-3 receptor (NK3R) agonist with an IC50 value of 3 nM. [MePhe7]-Neurokinin B is a potential regulator of pulsatile gonadotropin-releasing hormone (GnRH) secretion via activation of the neurokinin-3 receptor (NK3R)[1].
[IC 50]

NK3: 3 nM (IC50)
[References]

[1] Misu R, et, al. Structure-activity relationship study of tachykinin peptides for the development of novel neurokinin-3 receptor selective agonists. Bioorg Med Chem. 2013 Apr 15;21(8):2413-2417. DOI:10.1016/j.bmc.2013.01.036
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