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110952-22-2

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110952-22-2 Structure

110952-22-2 Structure

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[Name] 2-Naphthalenecarboxylic acid, 6-[(hydroxyimino)(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)methyl]-
[CAS] 110952-22-2
[Synonyms] 2-Naphthalenecarboxylic acid, 6-[(hydroxyimino)(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)methyl]-
[Molecular Formula] C26H27NO3
[MOL File] 110952-22-2.mol
[Molecular Weight] 401.5

Chemical Properties	Back Directory
[Boiling point ] 578.7±50.0 °C(Predicted)
[density ] 1.17±0.1 g/cm3(Predicted)
[pka] 4.10±0.30(Predicted)

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[Uses] BMS-185354 is a selective RARγ activator with an EC50 value of 28 nM. BMS-185354 is promising for research of cancers[1].
[IC 50] RXRγ: 28 nM (EC₅₀)
[References] [1] Ostrowski J, et al. Serine 232 and methionine 272 define the ligand binding pocket in retinoic acid receptor subtypes. J Biol Chem. 1998 Feb 6;273(6):3490-5. DOI:10.1074/jbc.273.6.3490

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