| Identification | Back Directory | [Name]
1-((3,5-dichloro)-2,6-dihydroxy-4-methoxyphenyl)-1-hexanone | [CAS]
111050-72-7 | [Synonyms]
1-(3,5-Chloro-2,6-dihydroxy-4-methoxyphenyl)-1-Hexanone
1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one
1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexane-1-one
1-Hexanone, 1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)-
1-((3,5-dichloro)-2,6-dihydroxy-4-methoxyphenyl)-1-hexanone | [Molecular Formula]
C13H16Cl2O4 | [MDL Number]
MFCD00467670 | [MOL File]
111050-72-7.mol | [Molecular Weight]
307.17 |
| Chemical Properties | Back Directory | [storage temp. ]
2-8°C | [solubility ]
DMSO: soluble20mg/mL, clear | [form ]
powder | [color ]
white to beige | [InChI]
1S/C13H16Cl2O4/c1-3-4-5-6-7(16)8-11(17)9(14)13(19-2)10(15)12(8)18/h17-18H,3-6H2,1-2H3 | [InChIKey]
VUDQSRFCCHQIIU-UHFFFAOYSA-N | [SMILES]
Clc1c(c(c(c(c1O)C(=O)CCCCC)O)Cl)OC |
| Hazard Information | Back Directory | [Uses]
DIF-1 is a cell growth suppressor that promotes differentiation in HL-60 cells. | [Definition]
ChEBI: A differentiation-inducing factor that is hexaphenone bearing two chloro substituents at positions 3 and 5, two hydroxy substituents at positions 2 and 6 as well as a single methoxy substituent at position 4. A secreted, chlorinated molecule that controls
ell fate during development of Dictyostelium cells. | [Biological Activity]
DIF-1 (differentiation-inducing factor-1) is isolated from a Dictyostelium slime moldand is used to inhibit proliferation/promote differentiation in various cell lines.''DIF-1 is a cell differentiation inducing factor.
Differentiation-inducing factor-1 (DIF-1) blocks the migration and invasion of cells and decreases the expression of matrix metalloproteinase-2. It prevents the proliferation of cells using glycogen synthase kinase-3 (GSK-3)-dependent mechanism. DIF-1 is more active when compared to DIF-2 in promoting stalk cell differentiation under submerged assay conditions. |
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| Company Name: |
Energy Chemical
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| Telephone: |
400-0056266 |
| Website: |
www.energy-chemical.com |
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