| Identification | Back Directory | [Name]
sadopine | [CAS]
111127-62-9 | [Synonyms]
sadopine
3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-[2-(trifluoromethyl)phenyl]-, 3-[2-[[2-[[(1,1-dimethylethoxy)carbonyl]amino]-4-(methylthio)-1-oxobutyl]amino]ethyl] 5-ethyl ester | [Molecular Formula]
C30H40F3N3O7S | [MOL File]
111127-62-9.mol | [Molecular Weight]
643.71 |
| Hazard Information | Back Directory | [Description]
Sadopine is an excellent high affinity, high specific activity radioligand to label selectively the DHP receptor of L-type Ca2+ channels in tissue sections as well as in membrane fragments. | [Uses]
Sadopine is an allosteric modulator for dihydropyridine receptor ((-)Sadopine as positive allosteric modulator and (+)Sadopine as negative allosteric modulator). Sadopine interacts with dihydropyridine (DHP)-sensitive L-type calcium channels[1]. | [References]
[1] Groebe DR. In search of negative allosteric modulators of biological targets. Drug Discov Today. 2009 Jan;14(1-2):41-9. DOI:10.1016/j.drudis.2008.09.011 |
|
|