| Identification | Back Directory | [Name]
C16-PHYTOCERAMIDE | [CAS]
111149-09-8 | [Synonyms]
C16-PHYTOCERAMIDE
N-16:0 Phytosphingosine
C16 Phytoceramide (t18:0/16:0)
N-HEXADECANOYL-PHYTOSPHINGOSINE
Hexadecanamide, N-[(1S,2S,3R)-2,3-dihydroxy-1-(hydroxymethyl)heptadecyl]- | [Molecular Formula]
C34H69NO4 | [MDL Number]
MFCD08703057 | [MOL File]
111149-09-8.mol | [Molecular Weight]
555.92 |
| Hazard Information | Back Directory | [Description]
C16 Phytoceramide (t18:0/16:0) is a phytoceramide, which is a family of sphingolipids found in the intestine, kidney, and extracellular spaces of the stratum corneum of the mammalian epidermis. C16 Phytoceramide (t18:0/16:0) is composed of a phytosphingosine backbone amine-linked to a C16 fatty acid chain. The levels of C16 phytoceramide (t18:0/16:0) increase following heat stress in S. cerevisiae. It has been used with other ceramides to create stratum corneum substitutes to study percutaneous penetration and psoriasis in vitro. [Matreya, LLC. Catalog No. 2035] | [Uses]
Armillaramide (Desulfated ircisulfamide) is an ester product. | [Definition]
ChEBI: N-hexadecanoylphytosphingosine is a phytoceramide compound having a hexadecanoyl group attached to the nitrogen atom. It is a N-acylphytosphingosine and a N-palmitoyl-sphingoid base. | [References]
[1] M. W. CROSSMAN C H. Biosynthesis of phytosphingosine by the rat.[J]. The Journal of Biological Chemistry, 1977, 22 1: 5815-5819. DOI: 10.1016/s0021-9258(17)40095-0
[2] YUKIKO MIZUTANI Yasuyuki I Akio Kihara. Identification of the human sphingolipid C4-hydroxylase, hDES2, and its up-regulation during keratinocyte differentiation[J]. FEBS Letters, 2004, 563 1: Pages 93-97. DOI: 10.1016/s0014-5793(04)00274-1
[3] DAVID J. MONTEFUSCO. Distinct Signaling Roles of Ceramide Species in Yeast Revealed Through Systematic Perturbation and Systems Biology Analyses[J]. Science Signaling, 2013, 6 299. DOI: 10.1126/scisignal.2004515
[4] MIRANDA DE JAGER . Preparation and characterization of a stratum corneum substitute for in vitro percutaneous penetration studies[J]. Biochimica et biophysica acta. Biomembranes, 2006, 1758 5: Pages 636-644. DOI: 10.1016/j.bbamem.2006.04.001
[5] LINE HOLLESEN BASSE Joke A B Dani?l Groen. Permeability and lipid organization of a novel psoriasis stratum corneum substitute[J]. International Journal of Pharmaceutics, 2013, 457 1: Pages 275-282. DOI: 10.1016/j.ijpharm.2013.08.086 |
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