| Identification | Back Directory | [Name]
NF110 | [CAS]
111150-22-2 | [Synonyms]
NF110
4,4',4'',4'''-[Carbonylbis[imino-5,1,3-benzenetriylbis(carbonylimino)]]tetrakisbenzenesulfonicacidtetrasodiumsalt
4-[[3-[[3,5-bis[(4-sulfonatophenyl)carbamoyl]phenyl]carbamoylamino]-5-[(4-sulfonatophenyl)carbamoyl]benzoyl]amino]benzenesulfonate | [Molecular Formula]
C41H28N6O17S4.4Na | [MDL Number]
MFCD09038569 | [MOL File]
111150-22-2.mol | [Molecular Weight]
1096.92 |
| Hazard Information | Back Directory | [Uses]
NF 110 is a potent P2X3 receptor antagonist. | [Biological Activity]
High affinity P2X 3 receptor antagonist (K i values are 36, 82 and 4144 nM for P2X 3 , P2X 1 and P2X 2 recombinant receptors respectively). Shows no activity at P2Y 1 , P2Y 2 and P2Y 11 receptors (IC 50 > 10 μ M). Potently inhibits α , β -meATP-evoked desensitizing currents in rat DRG neurons (IC 50 = 527 nM). Shows antitumor activity against several tumor types. | [in vivo]
NF110 shows potency at Endogenous P2X Receptors in Rat DRG Neurons, with a peak amplitude of 675 pA[1]. | [storage]
Desiccate at RT |
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| Company Name: |
BOC Sciences
|
| Tel: |
|
| Website: |
https://www.bocsci.com |
| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
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