| Identification | Back Directory | [Name]
5,6,7,8,9,10-HEXAHYDRO-2-(4-METHOXYPHENYL)CYCLOHEPTA[B]PYRAZOLO[3,4-D]PYRIDIN-3(2H)-ONE | [CAS]
111205-55-1 | [Synonyms]
CGS 20625
5,6,7,8,9,10-HEXAHYDRO-2-(4-METHOXYPHENYL)CYCLOHEPTA[B]PYRAZOLO[3,4-D]PYRIDIN-3(2H)-ONE
2-(4-Methoxyphenyl)-5,6,7,8,9,10-hexahydrocyclohepta[b]pyrazolo[3,4-d]pyridin-3(2H)-one
Cyclohepta[b]pyrazolo[3,4-d]pyridin-3(2H)-one,5,6,7,8,9,10-hexahydro-2-(4-methoxyphenyl)- | [Molecular Formula]
C18H19N3O2 | [MDL Number]
MFCD08703128 | [MOL File]
111205-55-1.mol | [Molecular Weight]
309.36 |
| Chemical Properties | Back Directory | [Boiling point ]
463.6±55.0 °C(Predicted) | [density ]
1.33±0.1 g/cm3(Predicted) | [storage temp. ]
Store at +4°C | [solubility ]
<30.94mg/ml in DMSO; <7.73mg/ml in ethanol | [form ]
Solid | [pka]
9.27±0.20(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
CGS 20625 is a potent, selective and orally active partial agonist for the central benzodiazepine receptor. CGS 20625 inhibits [3H]-flunitrazepam binding to central benzodiazepine receptors with an IC50 of 1.3 nM. CGS 20625 can be used for the research of pentylenetetrazol-induced seizures[1]. | [Definition]
ChEBI: LSM-3520 is a member of pyrazoles and a ring assembly. | [Biological Activity]
Selective, partial agonist for the benzodiazepine binding site of the GABA A receptor. Potently inhibits [3H]-flunitrazepam binding to central benzodiazepine receptors (IC 50 = 1.3 nM) and displays weak affinity for peripheral benzodiazepine (IC 50 = 0.68 - 2.25 μ M) and GABA binding sites (IC 50 > 10000 μ M). Displays anxiolytic activity in vivo following oral administration. | [References]
[1] Williams M, et al. CGS 20625, a novel pyrazolopyridine anxiolytic. J Pharmacol Exp Ther. 1989 Jan;248(1):89-96. PMID:2563294 |
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Wuhan Topule
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