| Identification | Back Directory | [Name]
Benzamide, 2-fluoro-6-[[2-[(1,2,3,4-tetrahydro-6-methoxy-2-methyl-7-isoquinolinyl)amino]-7H-pyrrolo[2,3-d]pyrimidin-4-yl]amino]- | [CAS]
1116236-15-7 | [Synonyms]
IGF-1R inhibitor-2
Benzamide, 2-fluoro-6-[[2-[(1,2,3,4-tetrahydro-6-methoxy-2-methyl-7-isoquinolinyl)amino]-7H-pyrrolo[2,3-d]pyrimidin-4-yl]amino]- | [Molecular Formula]
C24H24FN7O2 | [MOL File]
1116236-15-7.mol | [Molecular Weight]
461.49 |
| Hazard Information | Back Directory | [Uses]
IGF-1R inhibitor-2 (example 121) is an insulin-like growth factor-1 receptor (IGF-1R) inhibitor. Downregulation of IGF-1R can reverse the transformed phenotype of tumor cells and potentially render them susceptible to apoptosis[1]. | [IC 50]
IGF-1R | [References]
[1] Stanley Dawes Chamberlain, et al. IR receptor tyrosine kinase and ALK kinase for treating cancer. WO2009020990 A1. |
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