| Identification | Back Directory | [Name]
2-CHLORO-5H-PYRROLO[3,2-D]PYRIMIDINE | [CAS]
1119280-66-8 | [Synonyms]
2-chloro-5H-pyrrolo[3
2-Chloro-5H-pyrrolo[3,2-d...
2-CHLORO-5H-PYRROLO[3,2-D]PYRIMIDINE
2-chloro-1H-pyrrolo[3,2-d]pyrimidine
5H-Pyrrolo[3,2-d]pyriMidine, 2-chloro- | [Molecular Formula]
C6H4ClN3 | [MDL Number]
MFCD11869949 | [MOL File]
1119280-66-8.mol | [Molecular Weight]
153.57 |
| Chemical Properties | Back Directory | [Melting point ]
>230 °C | [density ]
1.531±0.06 g/cm3(Predicted) | [storage temp. ]
Inert atmosphere,2-8°C | [pka]
12.25±0.40(Predicted) | [Appearance]
Off-white to light yellow Solid |
| Hazard Information | Back Directory | [Synthesis]
2,4-Dichloro-5H-pyrrolo[3,2-d]pyrimidine (134 mg, 0.71 mmol) was used as a feedstock and mixed with NaHCO3 (66 mg, 0.78 mmol) and 10% Pd/C (1.52 mg) in ethanol (4 mL). The reaction mixture was stirred at room temperature for 2.5 h under hydrogen (3 psi) atmosphere. Upon completion of the reaction, the mixture was filtered through a diatomaceous earth plug and the filtrate was evaporated. The residue was purified by fast chromatography to afford 2-chloro-5H-pyrrolo[3,2-d]pyrimidine (90 mg, 88% yield).LC/MS analytical conditions: gradient elution of 20-100% CH3CN with 0.05% HCOOH (aqueous) over 5 min, retention time of 1.58 min, and a molecular ion peak of [M+H]+ of 154 detected. | [References]
[1] Patent: US2016/46597, 2016, A1. Location in patent: Paragraph 0220
[2] Journal of Medicinal Chemistry, 2018,
[3] Patent: CN105859726, 2016, A. Location in patent: Paragraph 0042; 0043; 0044 |
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NovoChemy Ltd.
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86-(0)21-31261262 373522135 |
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www.novochemy.com |
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