Log in | Join Free | china | japan | germany
ChemicalBook--->CAS DataBase List--->112037-78-2

112037-78-2

Request For Quotation
112037-78-2 Structure

112037-78-2 Structure
IdentificationBack Directory
[Name]

1-TRIFLUOROMETHYL-2,3,4,9-TETRAHYDRO-1H-B-CARBOLINE
[CAS]

112037-78-2
[Synonyms]

-carboline
3-Methyl &alpha
Norharmane (9H-Pyrido[3,4-b]indole, ß
1,2,3,4-Tetrahydro-1-(trifluoromethyl)-ß
(S)-1-Trichloromethyl-1,2,3,4-Tetrahydro-&beta
rac 1-Trichloromethyl-1,2,3,4-Tetrahydro-&beta
1,2,3,4-Tetrahydro-1-(trifluoroMethyl)--carboline
1-TRIFLUOROMETHYL-2,3,4,9-TETRAHYDRO-1H-B-CARBOLINE
1,2,3,4-TETRAHYDRO-1-(TRIFLUOROMETHYL)-BETA-CARBOLINE
1-(trifluoromethyl)-2,3,4,9-tetrahydro-1H-beta-carboline
1-trifluoromethyl-1,2,3,4-tetrahydro-9H-pyrido<3,4-b>indole
2,3,4,9-Tetrahydro-1-(trifluoromethyl)-1H-pyrido[3,4-b]indole
1-(trifluoromethyl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole
1H-Pyrido[3,4-b]indole, 2,3,4,9-tetrahydro-1-(trifluoromethyl)-
[Molecular Formula]

C12H11F3N2
[MDL Number]

MFCD00052089
[MOL File]

112037-78-2.mol
[Molecular Weight]

240.22
Chemical PropertiesBack Directory
[Melting point ]

147-149°C
[Boiling point ]

350.0±37.0 °C(Predicted)
[density ]

1.351±0.06 g/cm3(Predicted)
[pka]

16.63±0.40(Predicted)
Safety DataBack Directory
[Risk Statements ]

36/37/38
[Safety Statements ]

26-36/37/39
Hazard InformationBack Directory
[Mechanism of action]

Although βCCE and other β-carbolines are not endogenous BZR ligands (vide supra) and are not currently approved for clinical use, they are used to characterize different GABAA/BZR subtypes (based on a and g subunit composition) and function (e.g., the partial agonist abecarnil) toward the discovery of anxioselective drugs. In this regard, the β-carboline ring system is planar in comparison to the boat conformation of the 1,4-benzodiazepines; thus, β-carbolines have been useful to extend structure–activity relationship information for the agonist, antagonist, and inverse agonist pharmacophores of the various GABAA/BZR subtypes.
[Clinical Use]

Several β-carbolines have approximately 10-fold higher affinity for the BZR when compared to diazepam. The ethyl ester of β-carboline-3-carboxylic acid (βCCE), identified in human urine extracts as an artifact of the extraction procedure, has very high affinity for the BZR.
112037-78-2 suppliers list
Company Name: Career Henan Chemica Co
Tel: +86-0371-86658258 15093356674; , 15093356674;
Website: https://www.coreychem.com/
Company Name: Hangzhou Yuhao Chemical Technology Co., Ltd  
Tel: 0571-82693216
Website: www.chemyuhao.com
Company Name: United States Biological  
Tel: 1-800-520-3011
Website: www.usbio.net
Company Name: Chempro Tech Co., Ltd.   
Tel:
Website: www.chemicalbook.com
Company Name: Shanghai Fchemicals Technology Co., Ltd  
Tel: 021-36030322
Website: www.fchemicals.com
Company Name: MOLEKULA Ltd.  
Tel: +44 (0) 1747 831066
Website: www.molekula.co.uk
Company Name: Ryan Scientific, Inc.   
Tel: 843-884-4911 x 319
Website: www.ryansci.com
Company Name: Aagile Labs Division of Tyger Scientific  
Tel: 888-329-8990
Website: www.tygersci.com
Company Name: APAC Pharmaceutical, LLC  
Tel: +1(410) 997 5552
Website: www.apacpharma.com
Company Name: Advanced Technology & Industrial Co., Ltd.  
Tel: (852) 23902293
Website: www.advtechind.com
Company Name: Fulcrum Scientific Ltd.  
Tel: +44 1484 317 214
Website: www.chemicalbook.com/ShowSupplierProductsList702/0_EN.htm
Company Name: Interchim S.A.  
Tel: (33) 4 70 03 88 55
Website: www.interchim.com
Company Name: Shanghai Weile Chemical Technology Co., Ltd  
Tel: 086-21-64346188
Website: www.weilesci.com
Tags:112037-78-2 Related Product Information