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112294-81-2

112294-81-2 Structure

112294-81-2 Structure
IdentificationBack Directory
[Name]

4-Thia-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid, 6-(1-hydroxyethyl)-7-oxo-3-[(tetrahydro-1-oxido-3-thienyl)thio]-, monosodium salt, [5R-[3(1R*,3S*),5α,6α(R*)]]-
[CAS]

112294-81-2
[Synonyms]

4-Thia-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid, 6-(1-hydroxyethyl)-7-oxo-3-[(tetrahydro-1-oxido-3-thienyl)thio]-, monosodium salt, [5R-[3(1R*,3S*),5α,6α(R*)]]-
[Molecular Formula]

C12H15NO5S3.Na
[MOL File]

112294-81-2.mol
[Molecular Weight]

372.44
Hazard InformationBack Directory
[Uses]

Sulopenem (sodium)(CP-70429 (sodium)) is an orally active, parenteral penem antibiotic with broad-spectrum activities against Gram-positive and Gram-negative bacteria. Sulopenem has the potential for urinary tract infections and intra-abdominal infections treatment. Sulopenem is inactive against Pseudomonas aeruginosa and Xanthomonas maltophilia[1][2][3].
[References]

[1] Karlowsky JA, et al. In Vitro Activity of Sulopenem, an Oral Penem, against Urinary Isolates of Escherichia coli. Antimicrob Agents Chemother. 2018;63(1):e01832-18. Published 2018 Dec 21. DOI:10.1128/AAC.01832-18
[2] Minamimura M, et al. In vitro antibacterial activity and beta-lactamase stability of CP-70,429 a new penem antibiotic. Antimicrob Agents Chemother. 1993;37(7):1547-1551. DOI:10.1128/AAC.37.7.1547
[3] Nagashima M, et al. In vitro and in vivo activities of sulopenem compared with those of imipenem and cephalosporins. Jpn J Antibiot. 1996;49(4):303-323. PMID:8786623
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