| Identification | Back Directory | [Name]
scyliorhinin II | [CAS]
112748-19-3 | [Synonyms]
PubChem ID: 101569057
L-Methioninamide, L-seryl-L-prolyl-L-seryl-L-asparaginyl-L-seryl-L-lysyl-L-cysteinyl-L-prolyl-L-α-aspartylglycyl-L-prolyl-L-α-aspartyl-L-cysteinyl-L-phenylalanyl-L-valylglycyl-L-leucyl-, cyclic (7→13)-disulfide | [Molecular Formula]
C77H119N21O26S3 | [MOL File]
112748-19-3.mol | [Molecular Weight]
1851.09 |
| Chemical Properties | Back Directory | [Boiling point ]
2202.7±65.0 °C(Predicted) | [density ]
1.47±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [pka]
4.01±0.10(Predicted) | [Sequence]
Ser-Pro-Ser-Asn-Ser-Lys-Cys-Pro-Asp-Gly-Pro-Asp-Cys-Phe-Val-Gly-Leu-Met-NH2 |
| Hazard Information | Back Directory | [Uses]
Scyliorhinin II is a selective neurokinin-3 receptor agonist, with a Ki of 2.5 nM for neurokinin-3 receptor in rat cerebral cortex. | [in vivo]
Scyliorhinin II produces potent, dose-related reciprocal hindlimb scratching about equipotently with an ED50 of 0.08 nmol via intracerebroventricularly (i.c.v.) administration in mice[2]. | [References]
[1] Buck SH, et al. The dogfish peptides scyliorhinin I and scyliorhinin II bind with differential selectivity to mammalian tachykinin receptors. Eur J Pharmacol. 1987 Nov 24;144(1):109-11. DOI:10.1016/0014-2999(87)90017-3
[2] Raffa RB, et al. Scyliorhinin-I and -II induce reciprocal hindlimb scratching in mice: differentiation of spinal and supraspinal neurokinin receptors in vivo. Neurosci Lett. 1993 Aug 6;158(1):87-91. DOI:10.1016/0304-3940(93)90619-v |
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