ChemicalBook--->CAS DataBase List--->112856-44-7

112856-44-7

112856-44-7 Structure

112856-44-7 Structure
IdentificationBack Directory
[Name]

Losigamone
[CAS]

112856-44-7
[Synonyms]

AO33
AO-33
AO 33
losigame
Losigamon
ADD137022
ADD-137022
Losigamone
ADD 137022
5-[(2-Chlorophenyl)hydroxymethyl]-4-methoxyfuran-2(5H)-one
2(5H)-Furanone, 5-[(R)-(2-chlorophenyl)hydroxymethyl]-4-methoxy-, (5S)-rel-
[Molecular Formula]

C12H11ClO4
[MDL Number]

MFCD00871710
[MOL File]

112856-44-7.mol
[Molecular Weight]

254.67
Chemical PropertiesBack Directory
[Boiling point ]

480.1±45.0 °C(Predicted)
[density ]

1.39±0.1 g/cm3(Predicted)
[form ]

Solid
[pka]

12.32±0.20(Predicted)
[color ]

White to off-white
Hazard InformationBack Directory
[Uses]

Losigamone (AO-33) is an orally active antiepileptic compound. Losigamone blocks sodium channel. Losigamone stimulates the neuronal chloride channel and enhance chloride influx. Losigamone potentiates GABA-mediated responses and reduces epileptiform activity induced by chloride channel antagonists. Losigamone can be used for epilepsy research[1][2].
[References]

[1] Chen H, et al. Losigamone add-on therapy for focal epilepsy. Cochrane Database Syst Rev. 2019 Dec 11;12(12):CD009324. DOI:10.1002/14651858.CD009324.pub5
[2] Jones FA, et al. The anticonvulsant effects of the enantiomers of losigamone. Br J Pharmacol. 1999 Nov;128(6):1223-8. DOI:10.1038/sj.bjp.0702919
Spectrum DetailBack Directory
[Spectrum Detail]

Losigamone(112856-44-7)1HNMR
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69556-70-3

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