| Identification | Back Directory | [Name]
Platinum, [(1R,2R)-1,2-cyclohexane-1,2,3,3,4,4,5,5,6,6-d10-diamine-κN1,κN2][ethanedioato(2-)-κO1,κO2]-, (SP-4-2)- | [CAS]
1132819-16-9 | [Synonyms]
Platinum, [(1R,2R)-1,2-cyclohexane-1,2,3,3,4,4,5,5,6,6-d10-diamine-κN1,κN2][ethanedioato(2-)-κO1,κO2]-, (SP-4-2)- | [Molecular Formula]
C8H12N2O4Pt | [MOL File]
1132819-16-9.mol | [Molecular Weight]
395.28 |
| Hazard Information | Back Directory | [Uses]
Oxaliplatin-d10, is the labeled analogue of Oxaliplatin (O845075), which is platinum-based antineoplastic agent that is used in cancer chemotherapy. | [Biological Activity]
Oxaliplatin-d10 is intended for use as an internal standard for the quantification of oxaliplatin by GC- or LC-MS. Oxaliplatin is a platinum-containing DNA-crosslinking agent.1 It induces the formation of DNA inter- and intrastrand crosslinks and DNA-protein adducts, inhibits DNA and RNA synthesis, and induces apoptosis in cancer cells. Oxaliplatin is cytotoxic to cisplatin-sensitive A2780(1A9) and KB-3-1 cells and cisplatin-resistant A2780-E(80) and KB-CP20 cells (IC50s = 0.12, 0.39, 4.7, and 2.7 μM, respectively).2 It reduces tumor growth in an HCCLM3 mouse xenograft model when administered at doses of 5 or 10 mg/kg once per week.3 Formulations containing oxaliplatin have been used in the treatment of advanced colorectal cancer and as adjuvants in stage III colon cancer. | [References]
1.Alcindor, T., and Beauger, N.Oxaliplatin: A review in the era of molecularly targeted therapyCurr. Oncol.18(1)18-25(2011)
2.Rixe, O., Ortuzar, W., Alvarez, M., et al.Oxaliplatin, tetraplatin, cisplatin, and carboplatin: Spectrum of activity in drug-resistant cell lines and in the cell lines of the National Cancer Institute’s Anticancer Drug Screen panelBiochem. Pharmacol.52(12)1855-1865(1996)
3.Wang, Z., Zhou, J., Fan, J., et al.Oxaliplatin induces apoptosis in hepatocellular carcinoma cells and inhibits tumor growthExpert Opin. Investig. Drugs18(11)1595-1604(2009)
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