| Identification | Back Directory | [Name]
Telbivudine-d4 | [CAS]
1134182-00-5 | [Synonyms]
Telbivudine-d4
1-((2S,4R,5S)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-(methyl-d3)pyrimidine-2,4(1H,3H)-dione-6-d | [Molecular Formula]
C10H14N2O5 | [MOL File]
1134182-00-5.mol | [Molecular Weight]
242.23 |
| Hazard Information | Back Directory | [Uses]
Telbivudine-d4 is deuterium labeled Telbivudine. Telbivudine (Epavudine), an orally active thymidine nucleoside analog, is a potent antiviral inhibitor of hepatitis B virus (HBV) replication[1]. | [References]
[1] Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. DOI:10.1177/1060028018797110
[2] Kim JW, et al. Telbivudine: a novel nucleoside analog for chronic hepatitis B. Ann Pharmacother. 2006;40(3):472-478. DOI:10.1345/aph.1G027
[3] Zobel T, et al. Telbivudine Reduces Parvovirus B19-Induced Apoptosis in Circulating Angiogenic Cells. Viruses. 2019;11(3):227. Published 2019 Mar 6. DOI:10.3390/v11030227 |
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