| Identification | Back Directory | [Name]
AMCA-NHS | [CAS]
113721-87-2 | [Synonyms]
AMCA-NHS
AMCA-OSU
AMCA-H NHS
7-AMCA NHS ester
AMCA-H N-succinimidyl ester
7-AMINO-4-METHYL-3-COUMARINYLACETYL
7-(DiMethylaMino)couMarin-4-aceticcid-NHS
7-(Dimethylamino)coumarin-4-acetic acid-NHS
SUCCINIMIDYL-7-AMINO-4-METHYLCOUMARIN-3-ACETATE
(2,5-dioxopyrrolidin-1-yl) 2-(7-amino-4-methyl-2-o
N-SUCCINIMIDYL 7-AMINO-4-METHYL-3-COUMARINYLACETATE
7-AMINO-4-METHYL-3-COUMARINYLACETYL SUCCINIMIDYL ESTER
7-AMINO-4-METHYL-3-COUMARINACETIC ACID N-SUCCINIMIDYL ESTER
AMCA, SE [7-Amino-4-methyl-3-coumaricetic acid N-succinimidyl ester]
AMCA NHS, 7-Amino-4-methyl-3-coumarinacetic acid N-succinimidyl ester
AMCA, SE [7-AMino-4-Methyl-3-couMarinacetic acid N-succiniMidyl ester]
2,5-Pyrrolidinedione, 1-[[(7-aMino-4-Methyl-2-oxo-2H-1-benzopyran-3-yl)acetyl]oxy]-
2H-1-Benzopyran-3-acetic acid, 7-amino-4-methyl-2-oxo-, 2,5-dioxo-1-pyrrolidinyl ester | [Molecular Formula]
C16H14N2O6 | [MDL Number]
MFCD00036170 | [MOL File]
113721-87-2.mol | [Molecular Weight]
330.29 |
| Chemical Properties | Back Directory | [Boiling point ]
559.4±60.0 °C(Predicted) | [density ]
1.50±0.1 g/cm3(Predicted) | [storage temp. ]
−20°C | [solubility ]
DMF: soluble | [form ]
A solid | [pka]
1.69±0.20(Predicted) | [Appearance]
Light yellow solid | [ex/em]
353/455 nm | [ε(extinction coefficient)]
19000 L⋅mol−1⋅cm−1 | [BRN ]
9007679 | [InChI]
InChI=1S/C16H14N2O6/c1-8-10-3-2-9(17)6-12(10)23-16(22)11(8)7-15(21)24-18-13(19)4-5-14(18)20/h2-3,6H,4-5,7,17H2,1H3 | [InChIKey]
ILKQVTIMOGNSAS-UHFFFAOYSA-N | [SMILES]
C1(=O)OC2=CC(N)=CC=C2C(C)=C1CC(ON1C(=O)CCC1=O)=O |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
36/37/38 | [Safety Statements ]
26-36 | [WGK Germany ]
3 | [F ]
8-10-21 | [HS Code ]
3212900000 | [Storage Class]
11 - Combustible Solids | [Hazard Classifications]
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
| Hazard Information | Back Directory | [Description]
Activated NHS-ester of AMCA (aminomethyl coumarin acetate) dye. This NHS ester is an amine-reactive dye for labeling of amine groups in proteins, peptides, amino-modified oligos, and other target molecules.
AMCA is one of the brightest blue fluorescent dyes. This fluorophore has a relatively large Stoke’s shift, high resistance to photobleaching, and pH-independent fluorescence from pH 4 to 10. AMCA is a widely used fluorophore for multiple-color labeling due to its minimal fluorescence overlap with green- and longer wavelength-emitting fluorescent dyes. | [Chemical Properties]
Appearance: Pale yellow solid
ex/em: 353/455 nm
Extinction coefficient (ε): 19000 L??mol??1??cm??1 | [Uses]
AMCA-H NHS ester reacts with primary amines at pH 7.0-9.0. Suitable for labeling lysyl residues in proteins. | [Abs/Em Maxima]
348/435 nm | [Fluoresene quantum yield]
0.91 | [Extinction Coefficient]
17400 | [CF260]
0.16 | [CF280]
0.13 |
|
| Company Name: |
INTATRADE GmbH
|
| Tel: |
+49 3493/605464 |
| Website: |
www.intatrade.de |
|