| Identification | Back Directory | [Name]
ethyl 4-(((2R,3R,4S,5R,6S)-4,5-bis(benzo[d][1,3]dioxol-5-ylcarbamoyloxy)-2-(hydroxymethyl)-6-methoxy-tetrahydro-2H-pyran-3-yloxy)carbonyl)benzoate | [CAS]
1137359-47-7 | [Synonyms]
BRD7552
CS-1560
BRD7552 >=98% (HPLC)
BRD 7552;BRD-7552;BRD7552
Methyl [2,3-O-bis(Benzo[1,3]dioxol-5-yl-carbamoyl)]-4-O-(4-ethoxycarbonyl-phenylcarbamoyl)-α-D-glucopyranoside
α-D-Glucopyranoside, methyl, 2,3-bis(N-1,3-benzodioxol-5-ylcarbamate) 4-[N-[4-(ethoxycarbonyl)phenyl]carbamate]
ethyl 4-(((2R,3R,4S,5R,6S)-4,5-bis(benzo[d][1,3]dioxol-5-ylcarbamoyloxy)-2-(hydroxymethyl)-6-methoxy-tetrahydro-2H-pyran-3-yloxy)carbonyl)benzoate | [Molecular Formula]
C33H33N3O15 | [MDL Number]
MFCD28133407 | [MOL File]
1137359-47-7.mol | [Molecular Weight]
711.63 |
| Chemical Properties | Back Directory | [Boiling point ]
757.6±60.0 °C(Predicted) | [density ]
1.53±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMF: 25 mg/ml; DMF:PBS (pH 7.2) (1:5): 0.2 mg/ml; DMSO: 20 mg/ml; Ethanol: 10 mg/ml | [form ]
A crystalline solid | [pka]
11.81±0.20(Predicted) | [color ]
White to off-white | [InChIKey]
WCJITTLHDWXESU-PSUBRWEKNA-N | [SMILES]
C(OCC)(=O)C1=CC=C(C(O[C@H]2[C@H](OC(=O)NC3C=C4C(=CC=3)OCO4)[C@@H](OC(=O)NC3C=C4C(=CC=3)OCO4)[C@@H](OC)O[C@@H]2CO)=O)C=C1 |&1:11,12,26,40,44,r| |
| Hazard Information | Back Directory | [Description]
BRD7552 is a small molecule that induces expression of pancreatic and duodenal homeobox 1 (PDX1), a transcription factor involved in pancreas development and function. BRD7552 dose-dependently increases PDX1 and insulin gene expression, as well as PDX1 protein levels, in PANC-1 cells. It also increases acetylation of histone H3 and trimethylation of H3K4 and H3K9. | [Uses]
BRD7552 upregulates PDX1 expression in both primary human islets and ductal cells. | [References]
[1] YUAN YUAN. A small-molecule inducer of PDX1 expression identified by high-throughput screening.[J]. Chemistry & biology, 2013, 20 12: 1513-1522. DOI: 10.1016/j.chembiol.2013.10.013 |
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BOC Sciences
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1-631-485-4226; 16314854226 |
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https://www.bocsci.com |
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