| Identification | Back Directory | [Name]
Z-PHE-TYR(TBU)-DIAZOMETHYLKETONE | [CAS]
114014-15-2 | [Synonyms]
Z-FY(T-BU)-DMK
Z-Phe-Tyr(tBu)-CHN2
Cbz-Phe-Tyr(O-t-Bu)-CHN2
CATHEPSIN L INHIBITOR III
Z-PHE-TYR(TBU)-DIAZOMETHYLKETONE
CBZ-PHE-TYR(O-T-BU)-CHN2;Z-PHE-TYR(TBU)-CHN2 | [Molecular Formula]
C31H34N4O5 | [MDL Number]
MFCD00672349 | [MOL File]
114014-15-2.mol | [Molecular Weight]
542.63 |
| Hazard Information | Back Directory | [Uses]
Z-Phe-Tyr(tBu)-diazomethylketone is a potent cathepsin L inhibitor. Z-Phe-Tyr(tBu)-diazomethylketone mediates reovirus disassembly. Z-Phe-Tyr(tBu)-diazomethylketone decreases viral detection[1][2]. | [Biological Activity]
Cell permeable: yes''Primary Target
Cathepsin L''Product does not compete with ATP.''Reversible: no | [IC 50]
cathepsin L | [References]
[1] Ebert DH, et al. Cathepsin L and cathepsin B mediate reovirus disassembly in murine fibroblast cells. J Biol Chem. 2002 Jul 5;277(27):24609-17. DOI:10.1074/jbc.M201107200
[2] Perez-Bermejo JA, et al. SARS-CoV-2 infection of human iPSC-derived cardiac cells reflects cytopathic features in hearts of patients with COVID-19. Sci Transl Med. 2021 Apr 21;13(590):eabf7872. DOI:10.1126/scitranslmed.abf7872 |
|
| Company Name: |
BOC Sciences
|
| Tel: |
1-631-485-4226; 16314854226 |
| Website: |
https://www.bocsci.com |
| Company Name: |
BOC Sciences
|
| Tel: |
16314854226 |
| Website: |
www.bocsci.com |
|