| Identification | Back Directory | [Name]
2-Aminobenzylchloride | [CAS]
114059-99-3 | [Synonyms]
2-Aminobenzylchloride
Bromhexine Impurity 88
Benzenamine, 2-(chloromethyl)- | [Molecular Formula]
C7?H8?Cl?N? | [MDL Number]
MFCD11168298 | [MOL File]
114059-99-3.mol | [Molecular Weight]
141.6 |
| Questions And Answer | Back Directory | [Application]
2-Aminobenzyl chloride can undergo a 1,4 elimination reaction to form Aza-ortho-xylylenes. For example, compound (1-80) under the conditions of 22Cs2CO3/CH2Cl2 undergoes a 1,4 elimination to remove one molecule of HCl to form Aza-ortho-xylylenes. Then, under basic conditions, the configuration changes, and an intramolecular Diels-Alder reaction occurs, giving compound (1-81) in a very high yield with an ee value of 99%. |
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