| Identification | Back Directory | [Name]
APP+ | [CAS]
1141-41-9 | [Synonyms]
IDT307
IDT307 >=98% (HPLC)
4-(4-Dimethylamino)phenyl-1-methylpyridinium iodide
4-[p-(Dimethylamino)phenyl]-1-methylpyridinium iodide
4-[4-(Dimethylamino)phenyl]-N-methylpyridinium iodide | [Molecular Formula]
C14H17IN2 | [MDL Number]
MFCD03731236 | [MOL File]
1141-41-9.mol | [Molecular Weight]
340.203 |
| Chemical Properties | Back Directory | [Melting point ]
180-182 °C | [storage temp. ]
-20°C | [solubility ]
DMSO: soluble15mg/mL, clear | [form ]
powder | [color ]
orange to dark orange-red | [InChI]
1S/C14H17N2.HI/c1-15(2)14-6-4-12(5-7-14)13-8-10-16(3)11-9-13;/h4-11H,1-3H3;1H/q+1;/p-1 | [InChIKey]
CAMWVBRDIKKGII-UHFFFAOYSA-M | [SMILES]
[I-].[n+]1(ccc(cc1)c2ccc(cc2)N(C)C)C |
| Safety Data | Back Directory | [Hazard Codes ]
T | [Risk Statements ]
25 | [Safety Statements ]
45 | [RIDADR ]
UN 2811 6.1 / PGIII | [WGK Germany ]
3 | [Storage Class]
6.1A - Combustible acute toxic Cat. 1 and 2
very toxic hazardous materials | [Hazard Classifications]
Acute Tox. 2 Oral |
| Hazard Information | Back Directory | [Uses]
IDT307, an analog of the organic cation MPP+, is a specific fluorescent substrate for DAT (fluorescent substrate APP+)[1]. | [Biochem/physiol Actions]
IDT307 (APP+) is a fluorescent analogue of the dopaminergic neurotoxin MPP+ monoamine transporter substrate that fluoresces after uptake into cells. IDT307 is a substrate for the dopamine transporter (DAT), norepinephrine transporter (NET), and serotonin transporter (SERT). IDT307 (APP+) was found to label catecholamine neuronal cell bodies with high selectivity in midbrain and was used to investigate SERT function in lymphocytes and platelets. | [References]
[1] Tao Hu, et al. Molecular mechanisms of organic cation and anion transport at the blood‐CSF barrier. 01 April 2018. |
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